WHAT IS A CLINICAL TRIAL?
A clinical trial is a research study on human participants to determine whether a treatment is safe and effective. It aims to answer three key questions:
- Does the treatment work?
- Does it work better than other treatments for the same condition?
- Is it safe for different groups of patients?
Clinical trials are monitored by outside experts to safeguard participants’ health. Treatments go through several clinical trial ‘phases’ – I-IV – to track safety and effectiveness before and after being approved.
In interventional trials, participants are assigned to groups that receive either a treatment or a placebo (i.e., a ‘lookalike’ treatment that contains no actual treatment). Interventional trials allow researchers to evaluate the health and safety effects that are specifically caused by the treatment.
Observational studies do not involve providing new treatments to patients; instead, they aim to understand how participants behave in ‘real world’ settings by studying how people respond to the medications they are already taking. These studies give scientists a more realistic idea of the factors influencing patients’ health and treatment.
Phases of clinical trials
Researchers conduct clinical trials in phases, I through IV.
Phase I tests are primarily concerned with testing the safety of a medicine, so are conducted on a small group of – usually healthy – participants. In some case, like cancer treatments, the treatments are very powerful and so the Phase I trials go directly to patients.
In Phase II, participants who have the actual disease condition receive the treatment in order to test the safety and effectiveness of the new treatment in improving their condition.
In Phase III, larger groups of participants receive the treatment to confirm its effectiveness and safety. Phase III trials often compare the new treatment with other available ‘standard of care’ treatments.
Phase IV trials track the effects of long-term use and commonly reported side effects of a treatment after it is licensed for use by the public.
Why take part in a clinical trial?
Volunteers take part in clinical trials for a multitude of reasons – and participation is a very personal decision.
Participants have the opportunity to learn more about the treatment options for their condition from the medical professionals on the research team.
Through a better understanding of different measurements, participants gain information about the short- and long-term health impacts of a new treatment.
Participants may be able to access innovative treatments before they become widely available to the public.
Sharing insights to help others
Clinical trials can improve care for everyone by helping doctors understand and treat conditions in new ways, by improving the effectiveness of treatments, making them easier to take, or reducing their side effects.
By contributing to the generation of new information in clinical trials, participants help move science forward.
To decide whether to take part in a clinical trial you should understand why the clinical trial is being conducted and what will happen if you decide to take part. The study center will provide you with a document containing information about the trial. A member of the study staff will also explain the study and answer any questions. You can take the time to discuss with friends and family too.
You can visit ClinicalTrials.gov. You can also talk to your healthcare provider. Clinical Trials that are sponsored by Ipsen are listed here.
The results of clinical trials that are sponsored by Ipsen are provided in lay language summaries. You can also visit ClinicalTrials.gov and select the ‘results’ tab of each study to view in a tabular summary.