{"id":26410,"date":"2022-08-12T09:00:00","date_gmt":"2022-08-12T07:00:00","guid":{"rendered":"https:\/\/d36deud6t4mnhi.cloudfront.net\/press-releases\/ipsen-completes-acquisition-of-epizyme-expanding-its-portfolio-in-oncology\/"},"modified":"2023-09-27T17:21:25","modified_gmt":"2023-09-27T15:21:25","slug":"ipsen-completes-acquisition-of-epizyme-expanding-its-portfolio-in-oncology","status":"publish","type":"press_release","link":"https:\/\/www.ipsen.com\/press-releases\/ipsen-completes-acquisition-of-epizyme-expanding-its-portfolio-in-oncology\/","title":{"rendered":"Ipsen completes acquisition of Epizyme expanding its portfolio in oncology"},"content":{"rendered":"\n<p><strong>PARIS, FRANCE,<\/strong>&nbsp;12 August 2022 \u2013 Ipsen (Euronext: IPN; ADR: IPSEY) today announced the closing of the definitive merger agreement under which Ipsen has acquired Epizyme, Inc. (Epizyme). Pursuant to the transaction, Ipsen acquires all outstanding shares of Epizyme for $1.45 per share plus a contingent value right (CVR) of $1.00 per share. Epizyme now operates as \u2018an Ipsen company\u2019 at deal close.<\/p>\n\n\n\n<p>As part of the transaction, Ipsen acquires Epizyme\u2019s lead medicine, Tazverik<sup>\u00ae<\/sup>&nbsp;(tazemetostat), a first-in-class, chemotherapy-free EZH2<sup>a<\/sup>&nbsp;inhibitor, which was granted Accelerated Approval by the U.S. Food and Drug Administration (FDA) in 2020. It is currently indicated for adults with relapsed or refractory follicular lymphoma (FL) whose tumors are positive for an EZH2 mutation as detected by an FDA-approved test and who have received at least two prior systemic therapies, and for adult patients with relapsed or refractory follicular lymphoma who have no satisfactory alternative treatment options, as well as for adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.<sup>1<\/sup><\/p>\n\n\n\n<p>Ipsen also acquires Epizyme\u2019s first-in-class, oral SETD2 inhibitor development candidate, EZM0414, which was granted FDA Fast Track status in 2021 and is currently under evaluation in a recently initiated Phase I\/Ib trial in adult patients with relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma, as well as a portfolio of preclinical programs focusing on epigenetic targets.<\/p>\n\n\n\n<p>\u201cThroughout the pre-close phase of planning, we have continued to be impressed by the potential of Tazverik, as well as the rest of the pipeline. Now that the deal is closed, we are excited to be working closely with our Epizyme colleagues to leverage Ipsen\u2019s established infrastructure so that these medicines may reach more patients. Additionally, through this transaction Ipsen gains scientific expertise and we look forward to integrating the two teams which share the goal of delivering innovative treatment options to underserved patients,\u201d said David Loew, Chief Executive Officer of Ipsen.<\/p>\n\n\n\n<p><strong>About&nbsp;Tazverik<\/strong><sup><strong>\u00ae<\/strong><\/sup><strong>&nbsp;(tazemetostat)<\/strong><\/p>\n\n\n\n<p>Tazverik is a methyltransferase inhibitor indicated for the treatment of:<\/p>\n\n\n\n<ul type=\"disc\">\n<li>Adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.<\/li>\n\n\n\n<li>Adult patients with relapsed or refractory follicular lymphoma whose tumors are positive for an EZH2 mutation as detected by an FDA-approved test and who have received at least two prior systemic therapies.<\/li>\n\n\n\n<li>Adult patients with relapsed or refractory follicular lymphoma who have no satisfactory alternative treatment options.<\/li>\n<\/ul>\n\n\n\n<p>These indications are approved under accelerated approval based on overall response rate and duration of response. Post marketing studies are required to confirm the anticipated clinical benefit and retain the labeled Accelerated Approval indications.<\/p>\n\n\n\n<p>The most common (\u226520%) adverse reactions in patients with epithelioid sarcoma are pain, fatigue, nausea, decreased appetite, vomiting and constipation. The most common (\u226520%) adverse reactions in patients with follicular lymphoma are fatigue, upper respiratory tract infection, musculoskeletal pain, nausea and abdominal pain.<\/p>\n\n\n\n<p>View the U.S. Full Prescribing Information here:&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=oQUuvUgF0RW2vG57lEXzNaBtT3mdtOZYfu47LF4ofr0ppUIW5Mb3YQG8SGN_j2QfKNC8t5C6lc92WK-oLmJB81q0yWtwTxvwK2yhg8PYgDFr8GxvUY_nOy4JS8VQb9iAEoASsTHYwMqS11GCajJzII_5g9zAxlLNzwS-WNS_cuZenksjlsR-HVmNJhflDT7Wh7MqrB6iUsDnQjGeupcEtQ==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/www.epizyme.com\/wp-content\/uploads\/2021\/06\/TAZVERIK.pdf<\/u><\/strong><\/a><\/p>\n\n\n\n<p><strong>About EZM0414<\/strong><\/p>\n\n\n\n<p>EZM0414 is a potent selective, oral, small molecule, investigational drug agent that inhibits the histone methyltransferase, SETD2, which plays a role in oncogenesis. SETD2 methylates histone as well as non-histone proteins, and this activity is involved in several key biological processes including transcriptional regulation, RNA splicing, and DNA damage repair. Based on the preclinical data on SETD2 inhibition by EZM0414 in multiple settings, including high risk t(4;14) multiple myeloma (MM) and in other B-cell malignancies such as diffuse large B-cell lymphoma (DLBCL), the Company is conducting SET-101, a Phase 1\/1b study of EZM0414, for the treatment of adult patients with relapsed or refractory MM and DLBCL.<\/p>\n\n\n\n<p><strong>About&nbsp;follicular lymphoma<\/strong><sup><strong>2, 3<\/strong><\/sup><\/p>\n\n\n\n<p>Follicular lymphoma is a type of non-Hodgkin lymphoma (NHL) which is a cancer of the lymphatic system. Follicular lymphoma develops when the body makes abnormal B lymphocytes. These lymphocytes are a type of white blood cell&nbsp;that normally helps fight infections. When a patient has a lymphoma, the abnormal lymphocytes build up in the lymph nodes or other body organs. Follicular lymphoma is generally slow growing. Each year, 15-20,000 people in the U.S. are diagnosed with follicular lymphoma. Most affected individuals are diagnosed with advanced disease.<\/p>\n\n\n\n<p><strong>About&nbsp;epithelioid sarcoma<\/strong><sup><strong>4<\/strong><\/sup><\/p>\n\n\n\n<p>Epithelioid sarcoma is a rare, slow-growing type of soft tissue cancer. Most cases begin in the soft tissue under the skin of a finger, hand, forearm, lower leg or foot, though it can start in other areas of the body. Typically, epithelioid sarcoma starts as a small firm growth or lump that is painless. It usually starts out as a single growth, but multiple growths may occur by the time a person seeks medical help. Sometimes this sarcoma appears as ulcers that don\u2019t heal, looking like open wounds over the growths. It is estimated that 13,040 individuals received a diagnosis of soft tissue sarcomas in the U.S. in 2018 with a corresponding 5,150 deaths.<sup>5<\/sup><\/p>\n\n\n\n<p><strong>About&nbsp;diffuse large B-cell lymphoma<\/strong><sup><strong>6<\/strong><\/sup><\/p>\n\n\n\n<p>Diffuse large B cell lymphoma (DLBCL) is a type of NHL. NHL is a cancer of the lymphatic system. It develops when the body makes abnormal B lymphocytes. These lymphocytes are a type of white blood cell that normally help to fight infections. When a patient has a lymphoma, the abnormal lymphocytes build up in lymph nodes or other body organs. DLBCL grows quickly and treatment starts soon after diagnosis. DLBCL is the most common type of NHL in the U.S. and worldwide, accounting for about 22 percent of newly diagnosed cases of B-cell NHL in the U.S. More than 18,000 people in the U.S. are diagnosed with DLBCL each year.<sup>7<\/sup><\/p>\n\n\n\n<p><strong>About multiple myeloma<\/strong><sup><strong>8<\/strong><\/sup><\/p>\n\n\n\n<p>Multiple myeloma is a rare form of cancer characterized by excessive production (proliferation) and improper function of certain cells (plasma cells) found in the bone marrow. Excessive plasma cells may eventually mass together to form a tumor or tumors in various sites of the body, especially the bone marrow. When multiple tumors are present or the bone marrow has greater than 10% plasma cells, the term multiple myeloma is used. In 2019, over 32,000 individuals in the U.S. were diagnosed with this disease. It is believed that approximately 100,000 Americans currently have the disease.<\/p>\n\n\n\n<p><strong>About Ipsen&nbsp;<\/strong><\/p>\n\n\n\n<p>Ipsen is a global, mid-sized biopharmaceutical company focused on transformative medicines in Oncology, Rare Disease and Neuroscience. With Specialty Care sales of \u20ac2.6bn in FY 2021, Ipsen sells medicines in over 100&nbsp;countries. Alongside its external-innovation strategy, the Company\u2019s research and development efforts are focused on its innovative and differentiated technological platforms located in the heart of leading biotechnological and life-science hubs: Paris-Saclay, France; Oxford, U.K.; Cambridge, U.S.; Shanghai, China. Ipsen, excluding its Consumer HealthCare business, has around 4,500 colleagues worldwide and is listed in Paris (Euronext: IPN) and in the U.S. through a Sponsored Level&nbsp;I American Depositary Receipt program (ADR: IPSEY). For more information, visit&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=pHWV-2kf8i9mt0Re3kksUePm1dvhkCPCy8LCu0Bmff-QbQtdQeTIDcnXDxX0m6O2NuzGoqlAlppz_2M51o-c3w==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>ipsen.com<\/u><\/strong><\/a><\/p>\n\n\n\n<p><em>Tazverik<\/em><sup><em>\u00ae<\/em><\/sup><em>&nbsp;is a registered trademark of Epizyme.<\/em><\/p>\n\n\n\n<p><strong>Ipsen\u2019s Forward-Looking Statements<\/strong><\/p>\n\n\n\n<p>The forward-looking statements, objectives and targets contained herein are based on Ipsen\u2019s management strategy, current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. All of the above risks could affect Ipsen\u2019s future ability to achieve its financial targets, which were set assuming reasonable macroeconomic conditions based on the information available today. Use of the words \u2018believes\u2019, \u2018anticipates\u2019 and \u2018expects\u2019 and similar expressions are intended to identify forward-looking statements, including Ipsen\u2019s expectations regarding future events, including regulatory filings and determinations. Moreover, the targets described in this document were prepared without taking into account external growth assumptions and potential future acquisitions, which may alter these parameters. These objectives are based on data and assumptions regarded as reasonable by Ipsen. These targets depend on conditions or facts likely to happen in the future, and not exclusively on historical data. Actual results may depart significantly from these targets given the occurrence of certain risks and uncertainties, notably the fact that a promising medicine in early development phase or clinical trial may end up never being launched on the market or reaching its commercial targets, notably for regulatory or competition reasons. Ipsen must face or might face competition from generic medicine that might translate into a loss of market share. Furthermore, the research and development process involves several stages each of which involves the substantial risk that Ipsen may fail to achieve its objectives and be forced to abandon its efforts with regards to a medicine in which it has invested significant sums. Therefore, Ipsen cannot be certain that favorable results obtained during preclinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the medicine concerned. There can be no guarantees a medicine will receive the necessary regulatory approvals or that the medicine will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Other risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and healthcare legislation; global trends toward healthcare cost containment; technological advances, new medicine and patents attained by competitors; challenges inherent in new-medicine development, including obtaining regulatory approval; Ipsen\u2019s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Ipsen\u2019s patents and other protections for innovative medicines; and the exposure to litigation, including patent litigation, and\/or regulatory actions. Ipsen also depends on third parties to develop and market some of its medicines which could potentially generate substantial royalties; these partners could behave in such ways which could cause damage to Ipsen\u2019s activities and financial results. Ipsen cannot be certain that its partners will fulfil their obligations. It might be unable to obtain any benefit from those agreements. A default by any of Ipsen\u2019s partners could generate lower revenues than expected. Such situations could have a negative impact on Ipsen\u2019s business, financial position or performance. Ipsen expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. Ipsen\u2019s business is subject to the risk factors outlined in its registration documents filed with the French Autorit\u00e9&nbsp;des March\u00e9s Financiers. The risks and uncertainties set out are not exhaustive and the reader is advised to refer to Ipsen\u2019s 2021 Universal Registration Document, available on&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=pHWV-2kf8i9mt0Re3kksUbFfDTvX56viNIwWklaNbH3PpFQahBsvR7pTSqZ5Ax0bCx8v4b9m9XxLEEBUlJ60Hw==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>ipsen.com<\/u><\/strong><\/a><\/p>\n\n\n\n<p><strong><u>For further information:<\/u><\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Contacts<\/strong><\/td><td>&nbsp;<\/td><\/tr><tr><td><strong><u>Investors<\/u><\/strong><\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Craig Marks<\/strong>\n<p>&nbsp;<\/p>\n<p>Vice President, Investor Relations<\/p>\n<p><a title=\"\" href=\"mailto:craig.marks@ipsen.com\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>craig.marks@ipsen.com<\/u><\/strong><\/a><\/p>\n<p>+44 7584 349 193<\/p>\n<\/td><td><strong>Adrien Dupin de Saint-Cyr<\/strong>\n<p>&nbsp;<\/p>\n<p>Investor Relations Manager<\/p>\n<p><a title=\"\" href=\"mailto:adrien.dupin.de.saint.cyr@ipsen.com\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>adrien.dupin.de.saint.cyr@ipsen.com<\/u><\/strong><\/a><\/p>\n<p>+33 6 64 26 17 49<\/p>\n<\/td><\/tr><tr><td><strong><u>Media<\/u><\/strong>\n<p>&nbsp;<\/p>\n<p><u>&nbsp;<\/u><\/p>\n<p><strong>Ipsen:<\/strong><\/p>\n<\/td><td>&nbsp;<\/td><\/tr><tr><td><strong>Joanna Parish<\/strong>\n<p>&nbsp;<\/p>\n<p>Global Head of Franchise Communications<strong>&nbsp;&nbsp;&nbsp;&nbsp;<\/strong>Oncology<\/p>\n<p><a title=\"\" href=\"mailto:joanna.parish@ipsen.com\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>joanna.parish@ipsen.com<\/u><\/strong><\/a><\/p>\n<p>+44 7840 023 741<\/p>\n<\/td><td><strong>Ioana Piscociu (French media)<\/strong>\n<p>&nbsp;<\/p>\n<p>Senior Manager<\/p>\n<p>Global Media Relations<\/p>\n<p><a title=\"\" href=\"mailto:ioana.piscociu@ipsen.com\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>ioana.piscociu@ipsen.com<\/u><\/strong><\/a><\/p>\n<p>+33 6 69 09 12 96<\/p>\n<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>Elizabeth Kalina (U.S. media)<\/strong><\/p>\n\n\n\n<p>VP, Communications &amp; Patient Advocacy<\/p>\n\n\n\n<p><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=b4ARQYrdEb9IJA_BZuKYiIUQ6JLbJlkqCesD72mTEXMLwSrS7LeTpkdBgqoChRvkuMuY8jJTYQwTplZ_OCjaZjAXpNnCqvwpxUyyjauWkmwo4Hj2gBAt04YIlDfAR8Cb\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>elizabeth.kalina@ipsen.com<\/u><\/strong><\/a><\/p>\n\n\n\n<p>+1 857 331 0060<\/p>\n\n\n\n<p>\u03b1 Enhancer of zeste homolog 2.<\/p>\n\n\n\n<ol>\n<li>US Food and Drug Administration. Highlights Prescribing Information for Tazverik<sup>\u00ae<\/sup>&nbsp;(tazemetostat). Available at:&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40vnALpiBIj9-fDwDnqpz5JTPLe9Znsen7I2AUABEkvYHU2E07ZMBJPlFgVPQ0ojn6oZTkmDW9TZToIKEpmnKgxFm4fRlhetq-ik0b6wopB_6GuEfP34ltvBii_N1lJXxaKgEP3Uc7bZe7FUsdSzE0XOq388B3FGU-kw8Lt3QgJD9amWCbaPdAIZVdf8uIezY_3jXDtky576b1NkkAYROjrXCv-FCwNT-o2GsWRcIarmfv34L-hjtaGQ-d-PZyPyVww==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/213400s000lbl.pdf<\/u><\/strong><\/a>. Last accessed: June 2022<\/li>\n\n\n\n<li>Cancer Research UK. Follicular Lymphoma. Available at:&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40vnALpiBIj9-fDwDnqpz5JR0ZyOGXY0tDAjq1s7VCI4qsUEAHj0Ag9mF6tA0pM37F-p5mZyc6rOtcTsu5YAciPzkuzXUz-nG9xan8-zujUUahJSkDKrHt8TB7zLgFI2ttrEIeLbaAE4EN0Ci7IM4Y8zALvgqlqck8W0hxcYU__l6M7OIA29ZiOrpoRaQxLeBOm2kMlaIjj-qX800exmy6Y__PUy2uk4LVVUoW-nFClTfFr6srJRL8RVzSFl28-JBHu-bPDoGg8GNcGBPtd4o1HhbKSXdKpxkJuVlNh2IT6mVjoCbAPqR1_q6mfQCM63HB1wE66ridZyaYUJbu2JU4Fg=\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/www.cancerresearchuk.org\/about-cancer\/<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLppsAJH5AS3-6nDAN8DBAoU33fdzWrAznPmVWc3zEzzIqGIhc8bD6EDo9W3AayoXlkokyr0gVWhTWlbK8huTF68u6c2gsnL1mNbgWI9m2Aay2V9RZcdV6wCDdMB4WcjaZ_Yw6t4Tlp7eZOIvPKoRpMxVRitQfQ0SLU5-oJ2_hE4xU34T4FYAi24tzIXxSrbfum84BLwlEPcT2NcJmGPESJPv5uvFyqL-FboLq-Uf1q5id17o00fjzfNDgaCgPk1ECw==\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40vdwqVHEd5RunKauYjlWU_MUIq6kPgfQ8_6HPwZQdPZeGush-3DEnCAqmku8B8w_tr4uRRiaR8OC2-tvIMTFrAEly-wFQa3c6p34K_P1ysDDUD4l1qq3vFO1bd6KLa_BehaqnJ2h6x7l-3SzQ55itJSNnYC3-PYgPjm0xXE4QtZFHTAW5dodenIdsflOr63Sodk7DzOrtthsgqUeQnYpNebvOTu997YKy-3YjBvj2QkBZw9jRo1oeH7882RkZa-ZTORT6hEhdIeFWKzMQ5NTLbg8BWj26ncY0NqIelKVlb99GODtGKXhqt2hbpOvFHGjfzq6ix4HHCx94kSwEsOvSJHRVeVot7orDmM8di0IWAP04WMBaryzb-CQ224t-Urk-A==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>non-hodgkin-lymphoma\/types\/follicular-lymphoma#:~:text=Follicular%<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLqC-eM4qEMOeDUOcZ0d_g-Tw-e9ClCoBOU-wg6XZxZgS8wBkWV5pPzpSAJAuSuG5tnZggCl1fpvuU6aeVOf9dM3KNTBkLYLJpSfmGRUtzocPQbtBI0GnyvCplSBl22uDCNLFg0XzyAr1y1HOlyqzVP4CCz6No9HcRbpYKt_AinwED2zR4oQqeS6GFT_esuVRv_Ruq2gmsXj8s02Eb-kd7atxCFzcYUHOaot517dasdKnZwH4dubqV2sSfOtC5IaBEg==\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40jySulUqchcqybcgRnIlWwsA1paQz1hYZ_ML74KZ75smCX46LIn-NfgBuz3UzoFYIHpOolc2d1lxX9OtfCpgcFewUkxh8RDmn3GI55VWmrnfEIAXMNqtZdpf_F0WYDjtDc3V0sOBG3YCdPAPcYR-pRkQN_popCszleSxARo-S2gMkPRcYW6qOwrF7Ryc_uUpEnnDMIfQ-eAzGdD_Cr_L1xj-5J6zHrshUS_ssW7GHjkmzjseuhlpKxDDvZUajCR6EFivcLVIWZGnXIYaM_oUuLTjOz9WMcyESbU0wddJnIwEV1OKMzPGX18_e_LCfwkp-cWrEliW6DEoMp_ZqaxY2-VH6xom9wUXFVVl9Eud_HEkgRl9QOUuW9Uk29tnE0Ao3A==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>20lymphoma%20is%20a%20type,normally%20helps%20us%20fight%20infections<\/u><\/strong><\/a>. Last accessed June 2022<\/li>\n\n\n\n<li>Rarediseases.org. Follicullar Lymphoma. Available at:&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40ub0YiB3zaSSnQiNCTLOiezNkecWbn5g1Bd8Y0LoClPNFpkaKIeehCpkYcOJI2hXcsjqn3YAM1wYjrL-MfSYw9qgiKVj1ZsgCidLoF1qw7hYYnrY6pzoGOOYpJkbCXMzpQbVvEgqLWXF0OhQqv2dFML5mwUXxXKqCFQikjHoAA0dvfq9Ubr0Hyy8tg-dCWNJiLMKYvfKA6isx3eAJjkD1eQ=\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/rarediseases.org\/rare-diseases\/follicular-lymphoma<\/u><\/strong><\/a>. Last accessed June 2022.<\/li>\n\n\n\n<li>Mayo Clinic. Epithelioid sarcoma.Available at:<br><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40vnALpiBIj9-fDwDnqpz5JQfq846LD5OKye_2Yb70yNX-af-qCLOoM2Tz8TRcC7FY8Fj7UEGCpV2mw6FzpiIvo03v9DH7YyL_LPl-Tuporl1JQFAg1NNFmXHHaQkZMbi-4FKiOWcZWL3IfdOUGYgcCIY_LRmgeBxP-AwaopJuY9kbP3DRJGh_Cn-Nw4ZIzheFZKF7Rp5K6Guq7Ad3Mo0H43oATCqhUfIPf0-NIIit8EePsB6RKjtU7pwr3ASfG8-tmSV38T5rdXy5xsMaEztWh-4T2Dz_b2uE2u23XO-TCUIYDBNsY1Q7fjUAdVYe7foCatarqAaaBuq4pxtjSk5batBnBylQnmV9QCtaCLZ4-OVmqyA_TJqbr90ogBuaY24QQ==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/www.mayoclinic.org\/diseases-conditions\/epithelioid-sarcoma\/cdc-20392420#:~<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLprVngfP-nUFmJC8iobeOvVNUqHhOu9JvOAi8Cf4F5EuIW013W27P8w2NqiEaCWWws_i29wufkq8bXPBrFrVsb6JB8m14_gJXiQ1xMs-9T4PCJJHRHBi29eJ4wVJKEJ3rViqYh3Xq1tcnR2l0vWDAqeXD55WObHPIzncxp1cxUmIGvAYc_GixKY19wtVnwV4I0Kje_OcRe8bjOa7DA-0To9VKQhdM2NcukkmVBRdiMQt\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40ob38BLWzZ_fU-CS-e3p8COCnuvOxfW-DQznC0mXCYz88Q-dpzvP1ISPBNdhGLTrdeC5wbkWLA_lsE9bNw5wybc4-s2LUoSnYKSf1F0qf6fncMdO2kdmkYgHWIDgw1kVx9pKmWJFKS2fYCl_CedC643E865UHV8QiLTb-EUQxoRxKkMMmyrW-cnf4_po6OODoX8u8eR-hliZ4ahtyOAZlHFAHEj_KkQjKgQzQ20OyOlB8d3Eh8WlzDoYHG73AxxKKSNkyOc23XeZO4nwJUu2ODRGEhGowMQXqa_H3-Ze5Rmuw5q9-3BSsUZ07p1IwZuttg==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>:text=Epithelioid%20sarcoma%20is%20a%20rare,<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLpeSx6fPaNc28TQcNkCc7Rei-taU4c-qY7yX6QTAc776xcOS8Srykr5TC-82A2WquDduVzX5Xn5C-1WoYWm4OAvNGoJM5C8k8eP0pyXWvg4eQJNuynTj9G2LUE6UdRO8wd5DY0mh1X3ah0tmabvsk8iXoc1scHLc-5nQh4M5eOPcHZG0tjBEgUeKE3gpXD4Ir96CS1eYPOiB8VjajIA5qMUcEkbOWvDigM4eaJs6XdGK\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40jzjFLDevALCO_ufoYQCd7CKqc5_kzinoqBKih087DHJG-M3LwDj_q9GcE39zJ963bSSfgWIxYdCZu0ZPUWgzQ1GDxsIgtSnxA6mk9meeN03i-xjJss66gkDsYHc7PDbwrjKqmy52jR2l-2WNDwHCTf1cZcXxQT3IsD2LdQ1Yty8JGZhpfvV8cISDjAOgTsf9JRW8mQEjn103AlY8EyJaWUK-RDsvvu-OmIQ4j30kaNd9Q7z1EyfrAO-Tbl--IArDiWirzQgaqVCkkAKcWvZIUZ7rTdWL7-UqmOewKfm_xkMyRG_rBypvNzPoDD6Phuj_w==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>growth%20or%20lump%20that\u2019s%20painless<\/u><\/strong><\/a>. Last accessed June 2022.<\/li>\n\n\n\n<li>Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018.&nbsp;<em>CA Cancer J Clin.<\/em>&nbsp;2018;68(1):7-30. doi:10.3322\/caac.21442<\/li>\n\n\n\n<li>Cancer Research UK. Diffuse large B cell lymphoma. Available at:&nbsp;<a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40vnALpiBIj9-fDwDnqpz5JR0ZyOGXY0tDAjq1s7VCI4qsUEAHj0Ag9mF6tA0pM37F-p5mZyc6rOtcTsu5YAciPydM5L4_pz0BONNmN_GCunhP1M4cXse1YbmOVMlTExHtdUd6-Y4sVw8X7Q7juAXzztsukLZl9h8zRU89zsAZ-Rb4sP-Wf7IE2nrEo1WcmjC6-NuE86mhWTYq1Mj8R9I_RjJWcJDXd3pjO0zUKQSVoz1AnuNAbDeXkxXWcf2ZIEumcBffipc7oahhZ4Rsyp7xZTMyJZoZhrAqjgnZ95_pxUZGUMmad0nHXPfhYbQH2GeV4smWLZR3Z8w-eo58V_dGNRdTBsgrtgfrc7QEWh8ssdXk0sJIUtJPFqPW8a1mNU9ko-J0U6OhFa_p7z3xE-WyBo=\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/www.cancerresearchuk.org\/about-cancer\/<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLg_CwpmcO_htJ18YNVDfZlZETlAZUFHNlvSMij854p529VjpmHHn1NRVbaTmfaX3J4uo1CE8gasXBo6CsJU93Khg6WfkHloJ6yqyEuRPW2ueM5Ye48L9fJjyctQX97R5g5hLT_-yfjWd4n9LDLf7zhJwN5WNnBZIIW1yLIuXEKj-6thZcPF9w26kdTytnnPJKH_HSuXyJUvHW5HrwCXWKTy-X9RUomr4wP_4dOWc4qe_gGAQPTxoAWXpc2teypgM2DFky4QMvMErpS3UGuBQejCYkmeOwzk3ZQGg6smuJXEfySJSFlZ8tw_2USHQKd1oPw==\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40vdwqVHEd5RunKauYjlWU_MUIq6kPgfQ8_6HPwZQdPZewQZ6DWejZTbm33mCjVk_MSP89zronB_PZZ_iMS7IOJK55qUOm_TTvWYNblq6pJPQC9H917kjcoleSMZP1qhTp7VAYXi48BtprvRO2KMKEI7OucaDgjmoqGfB2L1DXIYXTO3Fwg2ZvzH6GNCSYNUHydY_lZKSWqGqN315eQqQclfTvUThuDAWDyfJl6erPPoO056X2LDVLQxYnYUFx8Dvz2Y9OJ8UwqJg9IhRctUZJJ4eZrqJx2JVho0IePY5ZFWU58opINsFZ9LgsMulI36xKrxFRwh5naYHJW92euinh61UNM6K77GOufNt1YkVsMSozuurVDn67j9WoZWq5YLovUpkW-5jPSNqkym8suhp_N_fn6V0URria1lyGr0EFACaMuJABvT31e1mZ0D3bVvhLw==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>non-hodgkin-lymphoma\/types\/diffuse-large-B-cell-lymphoma#:~:text=Diffuse%20large<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLvVeA0sali9M1Uo4nUIU6y4UcWVkoaB_zKgBSTZSbAGrCZrVkORej0PWeNo_7V9zK9-2bgIuLrc8SRyxRKC7P2S3ExWBldIPfwUGG8eFcXrqm2H_DZFpyZGU4YDJVJ2m0It0mVXoMVSot2OBdLLxnMItNZKwivZV41gzlmztQH1XTdZu3C9JyfPZ3M-uenGZpKtbJbQeTIVK-ox1exN4YnpI5Siq1XnNYmi0f_Qa61wJJx1YRlVJEiPeJd9X3jtEiDGwAp-aUTcwjVdgdM_1_s2gEf4yh3sbZvnMtwCsYp-o3SUXKYqzl-PZMq79EAPx7Q==\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40rNp33YQkX3xiXHJmibWsgbvPknv3yN-UIGjBy4tqbUbw6Tb0kVh4EabsL6UOnv8Wd3n91N0NMHNBfXEVpG86aHge6nWZK1-OhuU-RckYKXPiN9uNLJDoldMoYRJD_OezOZf2uj1p8szIFkPVzMnoqoD4v2B1Y0ZIXJPweojip-ksVSte4kYSR-MFiSGP3XjBt3ccfQEnjBsZIzuimRo2BpzOHXv5BGUkoBcyIAKeBbhbNJa9O8GOxgpq4EpAYJjtkA19t93ld2V4TX8mB-eVhqPV_mfeUjmRBe-LMNtOX7-38oxwPUmpGEj007HVBJ4WzZGADdRK7F3oo4uV44JIGfeuKOVPy2OtpaK-sJv0jkgvs1_wJSPNrCARtoDiE-XkA==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>%20B%20cell%20lymphoma%20(DLBCL)<\/u><\/strong><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=3_ORo4vR7Lk0WxH14lwzLnmTRzJr4THFkQVI5iuRND3bFBKEzE1M5le5gtpGCr4sLX-cqejQGVm1GZwZ4PjBSOp8gLdbVlXn6Dok7mSETbIkLdPGvekCIYTeDpwcK-vZAe01f3vqC4saJKmkFDLbT7mb7jv1ZVKcZfQLgj7KmsoHQ-_TGoetcMHHhA6I2IbmzX00LSZtk07XHaaPT580ptfLg7yzqlx4LG_AzTL09e43xefzeNFMNAD1peqo72xGMS2wWnHfOlv9NQlTrqCyTBRmebW4s53vMkHc_21rdKUi6ZfqPt2qPTf7I8zfBlJzeufnOOTFqbWYmLmAj9CDFg==\" target=\"_blank\" rel=\"nofollow noopener\"><br><\/a><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40hCE0G_4kotAE_FskDomUDnEm0m-2f1zl7wzJCRqg0vZ9qmePDepSFywza-xdN0IUablCQ4-S-fIHgcuS9ym9r22aQyhmrn4W5OUOgwVB3EjGE283BU0Xe4YRKQMpXNZvmtY9wPS3tJzibiMCidIHk8o-7PhitxxnGfx8eU__2JHKOBfwVmz6HsIdft4dr8TOl79HgbaVDtIVVbc-fgfmYwEu3JbDrf7pAkYJTUh7Qly8hj7GP4VNKydJWyC9cQLPgHhnT-JNev6hLv7MTjpJDmba1mipmLiQWFvCwy2hAbjG2x9SYtjwGVDOxqpCe004XTe2ApThZ1kBTWGhpd55QIg7wAA75pCMbzPnSB4I089y8aQ6bddyGW5NepAOXAoliQFlDxfdP6-DEn5jPlJPV0zIir0XVE29Z0955VuIOaB\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>%20is%20a%20type%20of,normally%20help%20to%20fight%20infections<\/u><\/strong><\/a>. Last accessed: June 2022<\/li>\n\n\n\n<li>Lymphoma Research Foundation. Diffuse Large B-Cell Lymphoma. Available at:<br><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40ijwVvHZU8iYHy9mZ5-lv_BVLCMT-FAF1RfKwKMglggJ3begi_gvYQIugrTMNNBPT7CfUXfU5L2tq2yab0VCs5kUweUygCqDyMcHF_jVr277oVhx2UK_mhaM4dJWUQH9JLOemxS5_Yz5taPJs6fgdxuuTKiDa5Hxwh8qBFA2m2xT\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/lymphoma.org\/aboutlymphoma\/nhl\/dlbcl\/<\/u><\/strong><\/a>. Last accessed: June 2022<\/li>\n\n\n\n<li>Raredisease.org. Multiple Myeloma. Available at:<br><a title=\"\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=JbSEN1zBIRPPzFIkozC40ub0YiB3zaSSnQiNCTLOiezNkecWbn5g1Bd8Y0LoClPNGMuubrAYzdZK9CTPwySYMibPPSBDEV3xhMEQh1q5yRrjQ23N8rCS3Iomv0io_HKhy4xpZ9TZr1XrE77WAKD-IWMj5pIXm_6CFGi1tQJ3u9wwHh1_elp8Oa5TeXIAyN5m25WP7lc4s_myeTykDEwmVQ==\" target=\"_blank\" rel=\"nofollow noopener\"><strong><u>https:\/\/rarediseases.org\/rare-diseases\/multiple-myeloma<\/u><\/strong><\/a>. Last accessed June 2022.<\/li>\n<\/ol>\n\n\n\n<p id=\"gnw_attachments_section-header\"><strong>Attachment<\/strong><\/p>\n\n\n\n<ul id=\"gnw_attachments_section-items\">\n<li><a title=\"Ipsen_Epizyme_PR_EN\" href=\"https:\/\/www.globenewswire.com\/Tracker?data=As7FOeSqnmTv61ycOtpn7whnxfsOc8OWLn5UNwZTGnc3LTL1ecrSsAc6-RXPQJxsTguZmJKb4N2DwscrtO8vbbYdvjwqbr7lecQSVlOu75rg5w80PlIjNed6L-KjSgnEl-Ep7KECUvgB37g8AT-63SQo7MO7rfCJp5zkvF4BZu4=\" target=\"_blank\" rel=\"nofollow noopener\">Ipsen_Epizyme_PR_EN<\/a><\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/ml-eu.globenewswire.com\/media\/NDI1YTdlMjQtNzkyMy00NjUyLTkwMGUtZDNlZWJhMTE2ZGQzLTEwMTA5NDM=\/tiny\/Ipsen-SA.png\" alt=\"\" \/><\/figure>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":16,"template":"","categories":[1801,1763,3556,3539,6364,1767,1771],"tags":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ipsen completes acquisition of Epizyme expanding its portfolio in oncology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ipsen.com\/press-releases\/ipsen-completes-acquisition-of-epizyme-expanding-its-portfolio-in-oncology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ipsen completes acquisition of Epizyme expanding its portfolio in oncology\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ipsen.com\/press-releases\/ipsen-completes-acquisition-of-epizyme-expanding-its-portfolio-in-oncology\/\" \/>\n<meta property=\"og:site_name\" content=\"Global\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-27T15:21:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/2023\/05\/17154440\/PR-final.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"856\" \/>\n\t<meta property=\"og:image:height\" content=\"446\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@ipsengroup\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" 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