{"id":752,"date":"2025-09-19T15:43:48","date_gmt":"2025-09-19T06:43:48","guid":{"rendered":"https:\/\/www.ipsen.com\/japan\/?post_type=press_release&#038;p=752"},"modified":"2025-11-26T07:01:48","modified_gmt":"2025-11-25T22:01:48","slug":"%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9","status":"publish","type":"press_release","link":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/","title":{"rendered":"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97"},"content":{"rendered":"\n<p>\u30d3\u30eb\u30d9\u30a4\u00ae\u306f\u3001\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\uff08Progressive Familial Intrahepatic Cholestasis :PFIC\uff09\u306b\u4f34\u3046\u305d\u3046\u75d2\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u305fIBAT \u963b\u5bb3\u85ac\u3067\u3042\u308a\u3001\u4f53\u91cd5 \u338f\u4ee5\u4e0a\u306e\u4e73\u5e7c\u5150\u304a\u3088\u3073\u5c0f\u5150\u3001\u6210\u4eba\u306b\u3068\u3063\u3066\u5916\u79d1\u7684\u4ecb\u5165\u3092\u4f34\u308f\u306a\u3044\u6cbb\u7642\u9078\u629e\u80a2\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u65e5\u672c\u3001\u6771\u4eac\u20152025 \u5e749 \u670819 \u65e5 \u2015 IPSEN \u682a\u5f0f\u4f1a\u793e\u306f\u672c\u65e5\u3001\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306b\u3064\u3044\u3066\u3001\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\uff08PFIC\uff09\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u3092\u52b9\u80fd\u53c8\u306f\u52b9\u679c\u3068\u3057\u3066\u539a\u751f\u52b4\u50cd\u7701\u304b\u3089\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u3092\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002PFIC \u306f\u3001\u80c6\u6c41\u9178\u304c\u809d\u81d3\u306b\u84c4\u7a4d\u3059\u308b\u3053\u3068\u3067\u9032\u884c\u6027\u306e\u809d\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u809d\u4e0d\u5168\u306b\u81f3\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u5e0c\u5c11\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u7dcf\u79f0\u3067\u3059\u3002\u3053\u306e\u75be\u60a3\u306f\u3001\u91cd\u5ea6\u306e\u304b\u3086\u307f\uff08\u305d\u3046\u75d2\uff09\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u8870\u5f31\u6027\u306e\u75c7\u72b6\u3092\u4f34\u3044\u3001\u63bb\u304d\u3080\u3057\u308a\u306b\u3088\u308b\u76ae\u819a\u640d\u50b7\u3001\u7761\u7720\u969c\u5bb3\u3001\u6613\u523a\u6fc0\u6027\u3001\u8a8d\u77e5\u6a5f\u80fd\u304a\u3088\u3073\u793e\u4f1a\u7684\u767a\u9054\u306e\u9045\u5ef6\u306a\u3069\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3067\u751f\u6d3b\u306e\u8cea\u3092\u8457\u3057\u304f\u640d\u306a\u3044\u307e\u3059\u3002PFIC \u306f\u3001\u65e5\u672c\u56fd\u5185\u3067\u63a8\u5b9a100 \u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<sup>1<\/sup><\/p>\n\n\n\n<p>\u300c\u65e5\u672c\u306b\u304a\u3051\u308b\u30d3\u30eb\u30d9\u30a4\u306e\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u306f\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u306e\u60a3\u8005\u3055\u3093\u306e\u751f\u6d3b\u306e\u8cea\u5411\u4e0a\u306b\u5411\u3051\u305f\u5f53\u793e\u306e\u53d6\u308a\u7d44\u307f\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u7bc0\u76ee\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u627f\u8a8d\u306b\u3088\u308a\u3001PFIC \u3068\u5171\u306b\u751f\u304d\u308b\u4e73\u5e7c\u5150\u3001\u5c0f\u5150\u3001\u6210\u4eba\u306e\u65b9\u3005\u306b\u5bfe\u3057\u3001\u65b0\u305f\u306a\u5916\u79d1\u7684\u4ecb\u5165\u3092\u4f34\u308f\u306a\u3044\u6cbb\u7642\u9078\u629e\u80a2\u304c\u63d0\u4f9b\u3055\u308c\u307e\u3059\u3002\u7279\u306b\u305d\u3046\u75d2\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u8ca0\u62c5\u306e\u5927\u304d\u3044\u75c7\u72b6\u306e\u6709\u610f\u7fa9\u306a\u7de9\u548c\u306b\u8ca2\u732e\u3059\u308b\u3053\u3068\u3092\u9858\u3063\u3066\u304a\u308a\u307e\u3059\u3002\u300d\u3068\u3001IPSEN \u682a\u5f0f\u4f1a\u793ePR \u62c5\u5f53\u8005\u306f\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30d3\u30eb\u30d9\u30a4\u306f1 \u65e51 \u56de\u7d4c\u53e3\u6295\u4e0e\u306e\u56de\u8178\u80c6\u6c41\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u963b\u5bb3\u5264\uff08IBATi\uff09\u3067\u3042\u308a\u3001\u809d\u81d3\u5185\u306e\u80c6\u6c41\u9178\u84c4\u7a4d\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3057\u305f\u3002PEDFIC \u8a66\u9a13\u306f\u3001\u3053\u308c\u307e\u3067\u3067PFIC \u3092\u5bfe\u8c61\u3068\u3057\u305f\u4e16\u754c\u6700\u5927\u898f\u6a21\u306e\u7b2cIII \u76f8\u8a66\u9a13\u3067\u3042\u308a\u3001\u3053\u306e\u8a66\u9a13\u3067\u30d3\u30eb\u30d9\u30a4\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u5c0f\u5150\u306f\u3001\u809d\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u305d\u3046\u75d2\u306e\u91cd\u75c7\u5ea6\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u307e\u3057\u305f\u3002 \u6cbb\u7642\u306f\u6982\u306d\u826f\u597d\u306a\u8010\u5bb9\u6027\u3092\u793a\u3057\u3001\u85ac\u5264\u95a2\u9023\u306e\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u4e0b\u75e2\u306f9.5\uff05\uff08PEDFIC 1 \u8a66\u9a13\uff09\u300112.1%\uff08PEDFIC 2 \u8a66\u9a13\uff09\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u300cPFIC \u3067\u306f\u3001\u75c7\u72b6\u7ba1\u7406\u3068\u809d\u6a5f\u80fd\u7dad\u6301\u306e\u305f\u3081\u3001\u65e9\u671f\u8a3a\u65ad\u3068\u65e9\u671f\u4ecb\u5165\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u30d3\u30eb\u30d9\u30a4\u306e\u627f\u8a8d\u306f\u3001\u60a3\u8005\u3068\u4ecb\u8b77\u8005\u306b\u3068\u3063\u3066\u3001\u304b\u3086\u307f\u3092\u8efd\u6e1b\u3057\u3001\u304b\u3086\u307f\u306b\u3088\u308b\u591c\u9593\u306e\u7761\u7720\u59a8\u3052\u3092\u7de9\u548c\u3057\u3001\u3055\u3089\u306b\u306f\u809d\u6a5f\u80fd\u306e\u7dad\u6301\u3082\u671f\u5f85\u3067\u304d\u308b\u3068\u3044\u3046\u70b9\u3067\u3001\u6cbb\u7642\u306e\u65b0\u305f\u306a\u9078\u629e\u80a2\u3068\u306a\u308a\u3046\u308b\u3068\u8003\u3048\u307e\u3059\u3002\u300d\u3068\u8fd1\u757f\u5927\u5b66\u5948\u826f\u75c5\u9662\u5c0f\u5150\u79d1\u306e\u8fd1\u85e4\u5b8f\u6a39\u533b\u5e2b\u306f\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-align-right\">\u4ee5\u4e0a<\/p>\n\n\n\n<h5 class=\"wp-block-heading has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-d4c9b110ceb849dcbac13f8d2e741e8c\">PFIC \u306b\u3064\u3044\u3066<\/h5>\n\n\n\n<p>\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\uff08PFIC\uff09\u306f\u3001\u809d\u81d3\u5185\u306b\u80c6\u6c41\u9178\u304c\u84c4\u7a4d\u3057\u3001\u809d\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u6700\u7d42\u7684\u306b\u809d\u4e0d\u5168\u306b\u81f3\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u7a00\u306a\u907a\u4f1d\u6027\u75be\u60a3\u306e\u7dcf\u79f0\u3067\u3059\u3002PFIC \u306b\u306f3 \u3064\u306e\u660e\u78ba\u306a\u30b5\u30d6\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3057\u307e\u3059\u3002PFIC1 \u578b\u304a\u3088\u3073PFIC 2 \u578b\u306f\u901a\u5e38\u3001\u4e73\u5150\u671f\u307e\u305f\u306f\u5e7c\u5150\u671f\u3068\u3044\u3063\u305f\u751f\u5f8c\u65e9\u671f\u306b\u767a\u75c7\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001PFIC 3 \u578b\u306f\u4e73\u5150\u671f\u304b\u3089\u601d\u6625\u671f\u307e\u3067\u306e\u9593\u306b\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<sup>2<\/sup> PFIC \u306e\u767a\u75c7\u306b\u7537\u5973\u5dee\u306f\u306a\u304f\u3001\u51fa\u751f5 \u4e07\u4ef6\u306b1 \u4f8b\u304b\u308910 \u4e07\u4ef6\u306b1 \u4f8b\u306e\u5272\u5408\u3067\u767a\u751f\u3057\u307e\u3059\u3002<sup>3 <\/sup>PFIC \u306f\u6210\u4eba\u671f\u306b\u767a\u75c7\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u901a\u5e38\u306f\u4e73\u5e7c\u5150\u671f\u306b\u767a\u75c7\u3057\u3066\u6700\u3082\u9032\u884c\u304c\u901f\u304f\u91cd\u7be4\u306a\u7d4c\u904e\u3092\u305f\u3069\u308a\u307e\u3059\u3002PFIC \u306f\u3001\u91cd\u5ea6\u306e\u304b\u3086\u307f\uff08\u305d\u3046\u75d2\uff09\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u8870\u5f31\u6027\u306e\u75c7\u72b6\u3092\u4f34\u3044\u3001\u63bb\u304d\u3080\u3057\u308a\u306b\u3088\u308b\u76ae\u819a\u640d\u50b7\u3001\u7761\u7720\u969c\u5bb3\u3001\u795e\u7d4c\u904e\u654f\u3001\u6ce8\u610f\u529b\u4f4e\u4e0b\u3001\u5b66\u696d\u6210\u7e3e\u306e\u4e0d\u632f\u306a\u3069\u3001\u60a3\u8005\u3055\u3093\u306e\u65e5\u5e38\u751f\u6d3b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002 \u3053\u308c\u307e\u3067\u3001\u75be\u60a3\u306e\u9032\u884c\u3068\u75c7\u72b6\u3092\u52b9\u679c\u7684\u306b\u7ba1\u7406\u3057\u3001\u751f\u6765\u306e\u809d\u6a5f\u80fd\u3092\u53ef\u80fd\u306a\u9650\u308a\u2fa7\u304f\u7dad\u6301\u3059\u308b\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-5b32634ff9b9c65ef2833d25f57e6c4c\">\u30d3\u30eb\u30d9\u30a4\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306b\u3064\u3044\u3066<\/h5>\n\n\n\n<p>\u30d3\u30eb\u30d9\u30a4\u306f1 \u65e51 \u56de\u6295\u4e0e\u306e\u56de\u8178\u80c6\u6c41\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u963b\u5bb3\u5264\uff08IBATi\uff09\u3067\u3042\u308a\u3001\u9060\u4f4d\u56de\u8178\u306b\u5c40\u6240\u7684\u306b\u4f5c\u7528\u3057\u3066\u3001\u80c6\u6c41\u9178\uff08\u4e3b\u306b\u80c6\u6c41\u9178\u5869\u306e\u5f62\u614b\uff09\u306e\u518d\u53d6\u8fbc\u3092\u6e1b\u5c11\u3055\u305b\u3001\u7d50\u8178\u3092\u901a\u904e\u3059\u308b\u80c6\u6c41\u9178\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u8840\u6e05\u4e2d\u306e\u80c6\u6c41\u9178\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u3002\u30d3\u30eb\u30d9\u30a4\u306f2021 \u5e746 \u6708\u3001EU \u306b\u304a\u3044\u3066\u3001\u751f\u5f8c6 \u304b\u6708\u4ee5\u4e0a\u306e\u5168\u30bf\u30a4\u30d7\u306e\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\uff08PFIC\uff09\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u521d\u3081\u3066\u306e\u85ac\u7269\u6cbb\u7642\u9078\u629e\u80a2\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3001\u7c73\u56fd\u3067\u306f\u3001PFIC \u306b\u3088\u308b\u80c6\u6c41\u3046\u3063\u6ede\u6027\u305d\u3046\u75d2\u3092\u6709\u3059\u308b\u751f\u5f8c3 \u304b\u6708\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u521d\u3081\u3066\u306e\u85ac\u7269\u6cbb\u7642\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u30d3\u30eb\u30d9\u30a4\u306fEU \u304a\u3088\u3073\u7c73\u56fd\u306b\u304a\u3044\u3066PFIC \u6cbb\u7642\u85ac\u3068\u3057\u3066\u30aa\u30fc\u30d5\u30a1\u30f3\u72ec\u5360\u6307\u5b9a\u3092\u53d6\u5f97\u3057\u3066\u3044\u307e\u3059\u30022023 \u5e746 \u6708\u306b\u306f\u3001\u7c73\u56fd\u306b\u304a\u3044\u3066\u751f\u5f8c12 \u304b\u6708\u4ee5\u4e0a\u306e\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\uff08ALGS\uff09\u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u3068\u3057\u305f\u80c6\u6c41\u3046\u3063\u6ede\u6027\u305d\u3046\u75d2\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3055\u308c\u3001ALGS \u306b\u5bfe\u3059\u308b\u30aa\u30fc\u30d5\u30a1\u30f3\u72ec\u5360\u6307\u5b9a\u3082\u53d6\u5f97\u3057\u307e\u3057\u305f\u3002 2024 \u5e74\u306b\u306f\u3001Kayfanda\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u88fd\u54c1\u540d\u3067\u3001\u751f\u5f8c6 \u304b\u6708\u4ee5\u4e0a\u306e\u30a2\u30e9\u30b8\u30fc\u30eb\u75c7\u5019\u7fa4\uff08ALGS\uff09\u60a3\u8005\u3055\u3093\u306b\u304a\u3051\u308b\u80c6\u6c41\u3046\u3063\u6ede\u6027\u305d\u3046\u75d2\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u3001\u4f8b\u5916\u7684\u306a\u72b6\u6cc1\u4e0b\u3067\u306e\u627f\u8a8d\u304c\u4ed8\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p><br>\u7c73\u56fd\u6dfb\u4ed8\u6587\u66f8\u306e\u8a73\u7d30\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044:label (fda.gov)<br>\u6b27\u5dde\u88fd\u54c1\u6982\u8981\uff08SmPC\uff09\u306e\u8a73\u7d30\u306f\u3053\u3061\u3089\u3092\u3054\u89a7\u304f\u3060\u3055\u3044:Bylvay, INN-odevixibat (europa.eu)<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h5 class=\"wp-block-heading has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-270159903cdb502355a79e9d8a7c72b1\">PEDFIC \u8a66\u9a13\u306b\u3064\u3044\u3066<\/h5>\n\n\n\n<p>PEDFIC \u306f\u3001PFIC \u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u308c\u307e\u3067\u3067\u6700\u5927\u898f\u6a21\u306e\u56fd\u969b\u7684\u306a\u7b2cIII \u76f8\u8a66\u9a13\u3067\u3059\u3002PEDFIC 1 \u306f\u3001\u30e9\u30f3\u30c0\u30e0\u5316\uff081:1:1\uff09\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u306e24 \u9031\u9593\u8a66\u9a13\u3067\u3042\u308a\u3001PFIC \u306e\u5c0f\u5150\u60a3\u8005\u3055\u3093\u306b\u304a\u3051\u308b2 \u7a2e\u985e\u306e\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\u6295\u4e0e\u91cf\uff0840\u03bcg\/kg \u307e\u305f\u306f120\u03bcg\/kg\uff09\u306e\u305d\u3046\u75d2\u306a\u3089\u3073\u306b\u8840\u6e05\u80c6\u6c41\u9178\u5024\u306e\u4f4e\u6e1b\u52b9\u679c\u304a\u3088\u3073\u8010\u5bb9\u6027\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u8a66\u9a13\u7d50\u679c\u306fThe Lancet \u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<sup>4<\/sup><br>\u7b2cIII \u76f8PEDFIC 1 \u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30d3\u30eb\u30d9\u30a4\u304cPFIC \u306b\u5bfe\u3059\u308b\u52b9\u679c\u7684\u3067\u65b0\u3057\u3044\u6cbb\u7642\u9078\u629e\u80a2\u3068\u306a\u308a\u5f97\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PEDFIC \u8a66\u9a13\uff08n=62\uff09\u3067\u306f\u3001\u6700\u521d\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b\u304b\u3086\u307f\u75c7\u72b6\u306b\u304a\u3044\u3066\u3001\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\u6295\u4e0e\u7fa4\u3067\u6709\u610f\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f\u3002\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u3055\u3093\u306e55\uff05\u304c\u305d\u3046\u75d2\u306e\u8efd\u6e1b\u304c\u8a8d\u3081\u3089\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f30\uff05\u3067\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u307e\u305f\u3001\u7b2c2 \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b24 \u9031\u6642\u70b9\u3067\u306e\u8840\u6e05\u80c6\u6c41\u9178\uff08sBA\uff09\u53cd\u5fdc\uff08sBA \u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308970\uff05\u4ee5\u4e0a\u306e\u6e1b\u5c11\u3001\u307e\u305f\u306f70\u03bcmol\/L \u4ee5\u4e0b\u306b\u6e1b\u5c11\u3057\u305f\u60a3\u8005\u3055\u3093\u306e\u6570\uff09\u3082\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\u7fa4\u3067\u306f\u6709\u610f\u306b\u591a\u304f\u306e\u60a3\u8005\u3055\u3093\u304csBA \u53cd\u5fdc\u3092\u9054\u6210\u3057\u300124 \u9031\u6642\u70b9\u3067sBA \u30ec\u30d9\u30eb\u304c\u6e1b\u5c11\u3057\u305f\u60a3\u8005\u3055\u3093\u304c33\uff05\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f0 \u540d\u3067\u3057\u305f\u3002<\/li>\n\n\n\n<li>\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\u306f\u6982\u306d\u826f\u597d\u306a\u8010\u5bb9\u6027\u3092\u793a\u3057\u3001\u8a66\u9a13\u671f\u9593\u4e2d\u306b\u85ac\u5264\u95a2\u9023\u306e\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u4e0b\u75e2\u306f9.5\uff05\u3067\u3057\u305f\u3002<\/li>\n<\/ul>\n\n\n\n<p>PEDFIC 2 \u306f\u3001PEDFIC 1 \u306e\u30aa\u30fc\u30d7\u30f3\u30e9\u30d9\u30eb\u5ef6\u2fa7\u8a66\u9a13\u3067\u3042\u308a\u3001PFIC \u60a3\u8005\u3055\u3093\u3092\u5bfe\u8c61\u306b\u3001\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8120\u03bcg\/kg \u30921\u65e51 \u56de\u6295\u4e0e\u3057\u305f\u969b\u306e\u6709\u52b9\u6027\u304a\u3088\u3073\u8010\u5bb9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u300172 \u9031\u9593\u8a66\u9a13\u3067\u3059\u3002 \u4e2d\u9593\u7d50\u679c\u306f<em>The Journalof Hepatology<\/em> \u8a8c\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<sup>5<\/sup><\/p>\n\n\n\n<h5 class=\"wp-block-heading has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-5e3382d6feddb4121c45a9d89abc543f\">\u30a4\u30d7\u30bb\u30f3\u306b\u3064\u3044\u3066<\/h5>\n\n\n\n<p>\u5f53\u793e\u306f\u3001\u304c\u3093\u3001\u5e0c\u5c11\u75be\u60a3\u3001\u795e\u7d4c\u79d1\u5b66\u3068\u3044\u30463 \u3064\u306e\u6cbb\u7642\u9818\u57df\u3067\u3001\u60a3\u8005\u3055\u3093\u306b\u9769\u65b0\u7684\u306a\u533b\u85ac\u54c1\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u306b\u6ce8\u529b\u3059\u308b\u56fd\u969b\u7684\u306a\u30d0\u30a4\u30aa\u533b\u85ac\u54c1\u4f01\u696d\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5f53\u793e\u306e\u30d1\u30a4\u30d7\u30e9\u30a4\u30f3\u306f\u5916\u90e8\u304b\u3089\u306e\u9769\u65b0\u7684\u6210\u679c\u3084\u6280\u8853\u306b\u5f37\u5316\u3055\u308c\u3001\u7d04100 \u5e74\u306b\u308f\u305f\u308b\u958b\u767a\u7d4c\u9a13\u3068\u7c73\u56fd\u3001\u30d5\u30e9\u30f3\u30b9\u3001\u82f1\u56fd\u306b\u62e0\u70b9\u3092\u7f6e\u304f\u30b0\u30ed\u30fc\u30d0\u30eb\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u306b\u3088\u3063\u3066\u652f\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u300240 \u30ab\u56fd\u4ee5\u4e0a\u306b\u5c55\u958b\u3059\u308b\u30c1\u30fc\u30e0\u3068\u4e16\u754c\u5404\u5730\u306e\u30d1\u30fc\u30c8\u30ca\u30fc\u30b7\u30c3\u30d7\u306b\u3088\u308a\u3001100 \u30ab\u56fd\u4ee5\u4e0a\u306e\u60a3\u8005\u3055\u3093\u306b\u533b\u85ac\u54c1\u3092\u304a\u5c4a\u3051\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30a4\u30d7\u30bb\u30f3\u306f\u30d1\u30ea\uff08\u30e6\u30fc\u30ed\u30cd\u30af\u30b9\u30c8: IPN\uff09\u306b\u4e0a\u5834\u3057\u3066\u304a\u308a\u3001\u7c73\u56fd\u3067\u306f\u30b9\u30dd\u30f3\u30b5\u30fc\u4ed8\u304d\u30ec\u30d9\u30ebI \u7c73\u56fd\u9810\u8a17\u8a3c\u5238\uff08ADR: IPSEY\uff09\u3092\u901a\u3058\u3066\u4e0a\u5834\u3057\u3066\u3044\u307e\u3059\u3002 \u8a73\u7d30\u306fipsen.com \u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-377ff7b087e4caaf0ed8185670e0ce93\">\u30a4\u30d7\u30bb\u30f3\u304a\u554f\u3044\u5408\u308f\u305b<\/h5>\n\n\n\n<p>PR \u62c5\u5f53070-3079-7969<\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-96fb6084c9a84424ffbf401970df430c\">\u514d\u8cac\u4e8b\u9805\u304a\u3088\u3073\u5c06\u6765\u306e\u898b\u901a\u3057\u306b\u95a2\u3059\u308b\u8a18\u8ff0<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u672c\u8cc7\u6599\u306b\u542b\u307e\u308c\u308b\u5c06\u6765\u306e\u898b\u901a\u3057\u306b\u95a2\u3059\u308b\u8a18\u8ff0\u3001\u76ee\u7684\u304a\u3088\u3073\u76ee\u6a19\u306f\u3001\u30a4\u30d7\u30bb\u30f3\u306e\u7d4c\u55b6\u6226\u7565\u3001\u73fe\u6642\u70b9\u3067\u306e\u898b\u89e3\u304a\u3088\u3073\u4eee\u5b9a\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u8a18\u8ff0\u306b\u306f\u3001\u65e2\u77e5\u304a\u3088\u3073\u672a\u77e5\u306e\u30ea\u30b9\u30af\u3084\u4e0d\u78ba\u5b9f\u6027\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u5b9f\u969b\u306e\u7d50\u679c\u3001\u696d\u7e3e\u307e\u305f\u306f\u4e8b\u8c61\u304c\u672c\u8cc7\u6599\u3067\u4e88\u60f3\u3055\u308c\u308b\u5185\u5bb9\u3068\u5927\u304d\u304f\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4e0a\u8a18\u306e\u30ea\u30b9\u30af\u306f\u3059\u3079\u3066\u3001\u30a4\u30d7\u30bb\u30f3\u304c\u8ca1\u52d9\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u5c06\u6765\u7684\u80fd\u529b\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u76ee\u6a19\u306f\u3001\u73fe\u6642\u70b9\u3067\u5165\u624b\u53ef\u80fd\u306a\u60c5\u5831\u306b\u57fa\u3065\u304d\u3001\u5408\u7406\u7684\u306a\u30de\u30af\u30ed\u7d4c\u6e08\u72b6\u6cc1\u3092\u60f3\u5b9a\u3057\u3066\u8a2d\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u300c\u4fe1\u3058\u308b\uff08believes\uff09\u300d\u300c\u4e88\u671f\u3059\u308b\uff08anticipates\uff09\u300d\u300c\u898b\u8fbc\u3080\uff08expects\uff09\u300d\u304a\u3088\u3073\u985e\u4f3c\u306e\u8868\u73fe\u306f\u3001\u5c06\u6765\u306e\u898b\u901a\u3057\u306b\u95a2\u3059\u308b\u8a18\u8ff0\u3092\u7279\u5b9a\u3059\u308b\u76ee\u7684\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001\u898f\u5236\u5f53\u5c40\u3078\u306e\u7533\u8acb\u3084\u305d\u306e\u6c7a\u5b9a\u306a\u3069\u306e\u3001\u30a4\u30d7\u30bb\u30f3\u304c\u5c06\u6765\u306e\u51fa\u6765\u4e8b\u306b\u3064\u3044\u3066\u6301\u3064\u898b\u8fbc\u307f\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u3055\u3089\u306b\u3001\u672c\u8cc7\u6599\u306b\u8a18\u8f09\u3055\u308c\u305f\u76ee\u6a19\u306f\u3001\u5916\u90e8\u6210\u2fa7\u306e\u60f3\u5b9a\u3084\u5c06\u6765\u306e\u8cb7\u53ce\u306e\u53ef\u80fd\u6027\u3092\u8003\u616e\u305b\u305a\u306b\u4f5c\u6210\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306b\u3088\u308a\u76ee\u6a19\u306e\u6839\u62e0\u3084\u6761\u4ef6\u304c\u5909\u66f4\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u76ee\u7684\u306f\u3001\u30a4\u30d7\u30bb\u30f3\u304c\u5408\u7406\u7684\u3068\u307f\u306a\u3059\u30c7\u30fc\u30bf\u304a\u3088\u3073\u524d\u63d0\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u76ee\u6a19\u306f\u5c06\u6765\u8d77\u3053\u308a\u3046\u308b\u72b6\u6cc1\u3084\u4e8b\u5b9f\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u904e\u53bb\u306e\u30c7\u30fc\u30bf\u306e\u307f\u306b\u4f9d\u5b58\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u7279\u5b9a\u306e\u30ea\u30b9\u30af\u3084\u4e0d\u78ba\u5b9f\u6027\u304c\u751f\u3058\u305f\u5834\u5408\u3001\u5b9f\u969b\u306e\u7d50\u679c\u306f\u3053\u308c\u3089\u306e\u76ee\u6a19\u304b\u3089\u5927\u304d\u304f\u9038\u8131\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7279\u306b\u3001\u958b\u767a\u521d\u671f\u6bb5\u968e\u3084\u81e8\u5e8a\u8a66\u9a13\u6bb5\u968e\u306b\u3042\u308b\u6709\u671b\u306a\u533b\u85ac\u54c1\u304c\u3001\u898f\u5236\u4e0a\u306e\u7406\u7531\u3084\u7af6\u4e89\u4e0a\u306e\u7406\u7531\u306a\u3069\u306b\u3088\u308a\u3001\u5e02\u5834\u306b\u6295\u5165\u3055\u308c\u306a\u3044\u3001\u3042\u308b\u3044\u306f\u5546\u696d\u7684\u76ee\u6a19\u3092\u9054\u6210\u3067\u304d\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30d7\u30bb\u30f3\u306f\u3001\u81ea\u8eab\u306e\u5e02\u5834\u30b7\u30a7\u30a2\u306e\u55aa\u5931\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5f8c\u767a\u533b\u85ac\u54c1\u3068\u306e\u7af6\u4e89\u306b\u307b\u307c\u78ba\u5b9f\u306b\u76f4\u9762\u3059\u308b\u304b\u3001\u307e\u305f\u306f\u76f4\u9762\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-small-font-size\">\u3055\u3089\u306b\u3001\u7814\u7a76\u958b\u767a\u30d7\u30ed\u30bb\u30b9\u306b\u306f\u8907\u6570\u306e\u6bb5\u968e\u304c\u3042\u308a\u3001\u5404\u6bb5\u968e\u306b\u304a\u3044\u3066\u30a4\u30d7\u30bb\u30f3\u304c\u76ee\u6a19\u3092\u9054\u6210\u3067\u304d\u305a\u3001\u591a\u984d\u306e\u6295\u8cc7\u3092\u884c\u3063\u305f\u533b\u85ac\u54c1\u306b\u95a2\u3059\u308b\u53d6\u308a\u7d44\u307f\u3092\u65ad\u5ff5\u305b\u3056\u308b\u3092\u5f97\u306a\u3044\u3068\u3044\u3046\u91cd\u5927\u306a\u30ea\u30b9\u30af\u304c\u4f34\u3044\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u30a4\u30d7\u30bb\u30f3\u306f\u3001\u524d\u81e8\u5e8a\u8a66\u9a13\u3067\u5f97\u3089\u308c\u305f\u826f\u597d\u306a\u7d50\u679c\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u305d\u306e\u5f8c\u78ba\u8a8d\u3055\u308c\u308b\u4fdd\u8a3c\u306f\u306a\u304f\u3001\u307e\u305f\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u304c\u5f53\u8a72\u533b\u85ac\u54c1\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u3092\u5341\u5206\u306b\u793a\u3059\u3053\u3068\u3092\u4fdd\u8a3c\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u533b\u85ac\u54c1\u304c\u5fc5\u8981\u306a\u85ac\u4e8b\u627f\u8a8d\u3092\u53d6\u5f97\u3059\u308b\u3053\u3068\u3001\u3042\u308b\u3044\u306f\u5546\u696d\u7684\u306b\u6210\u529f\u3059\u308b\u4fdd\u8a3c\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u57fa\u790e\u3068\u306a\u308b\u524d\u63d0\u304c\u4e0d\u6b63\u78ba\u3067\u3042\u3063\u305f\u308a\u3001\u3042\u308b\u3044\u306f\u30ea\u30b9\u30af\u3084\u4e0d\u78ba\u5b9f\u6027\u304c\u73fe\u5b9f\u5316\u3057\u305f\u5834\u5408\u3001\u5b9f\u969b\u306e\u7d50\u679c\u306f\u5c06\u6765\u306e\u898b\u901a\u3057\u306b\u95a2\u3059\u308b\u8a18\u8ff0\u306b\u8a18\u8f09\u3055\u308c\u305f\u5185\u5bb9\u3068\u5927\u304d\u304f\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u4ed6\u306e\u30ea\u30b9\u30af\u304a\u3088\u3073\u4e0d\u78ba\u5b9f\u6027\u306b\u306f\u3001\u696d\u754c\u306e\u4e00\u822c\u7684\u306a\u72b6\u6cc1\u304a\u3088\u3073\u7af6\u4e89\u3001\u91d1\u5229\u30fb\u70ba\u66ff\u30ec\u30fc\u30c8\u306e\u5909\u52d5\u3092\u542b\u3080\u4e00\u822c\u7684\u306a\u7d4c\u6e08\u7684\u8981\u56e0\u3001\u533b\u85ac\u54c1\u696d\u754c\u306e\u898f\u5236\u3084\u533b\u7642\u95a2\u9023\u6cd5\u306e\u5f71\u97ff\u3001\u533b\u7642\u8cbb\u6291\u5236\u306b\u5411\u3051\u305f\u4e16\u754c\u7684\u306a\u50be\u5411\u3001\u6280\u8853\u9032\u6b69\u3001\u65b0\u85ac\u958b\u767a\u3001\u7af6\u5408\u4ed6\u793e\u306b\u3088\u308b\u65b0\u85ac\u304a\u3088\u3073\u7279\u8a31\u53d6\u5f97\u3001\u85ac\u4e8b\u627f\u8a8d\u53d6\u5f97\u3092\u542b\u3080\u65b0\u85ac\u958b\u767a\u306b\u5185\u5728\u3059\u308b\u8ab2\u984c\u3001 \u30a4\u30d7\u30bb\u30f3\u304c\u5c06\u6765\u306e\u5e02\u5834\u72b6\u6cc1\u3092\u6b63\u78ba\u306b\u4e88\u6e2c\u3059\u308b\u80fd\u529b\u3001\u88fd\u9020\u4e0a\u306e\u56f0\u96e3\u307e\u305f\u306f\u9045\u5ef6\u3001\u56fd\u969b\u7d4c\u6e08\u306b\u304a\u3051\u308b\u91d1\u878d\u4e0d\u5b89\u5b9a\u6027\u304a\u3088\u3073\u30bd\u30d6\u30ea\u30f3\u30ea\u30b9\u30af\u3001\u30a4\u30d7\u30bb\u30f3\u306e\u9769\u65b0\u7684\u533b\u85ac\u54c1\u306b\u5bfe\u3059\u308b\u7279\u8a31\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u4fdd\u8b77\u306e\u6709\u52b9\u6027\u3078\u306e\u4f9d\u5b58\u3001\u306a\u3089\u3073\u306b\u7279\u8a31\u8a34\u8a1f\u3092\u542b\u3080\u8a34\u8a1f\u304a\u3088\u3073\u898f\u5236\u63aa\u7f6e\u3078\u306e\u66dd\u9732\u306a\u3069\u304c\u6319\u3052\u3089\u308c\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306b\u9650\u5b9a\u3055\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u30a4\u30d7\u30bb\u30f3\u306f\u4e00\u90e8\u306e\u533b\u85ac\u54c1\u306e\u958b\u767a\u304a\u3088\u3073\u8ca9\u58f2\u3092\u7b2c\u4e09\u8005\u306b\u4f9d\u5b58\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u306b\u3088\u308a\u591a\u984d\u306e\u30ed\u30a4\u30e4\u30eb\u30c6\u30a3\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30d1\u30fc\u30c8\u30ca\u30fc\u4f01\u696d\u306f\u3001\u30a4\u30d7\u30bb\u30f3\u306e\u4e8b\u696d\u6d3b\u52d5\u3084\u8ca1\u52d9\u5b9f\u7e3e\u306b\u640d\u5bb3\u3092\u4e0e\u3048\u308b\u3088\u3046\u306a\u884c\u52d5\u3092\u53d6\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u30a4\u30d7\u30bb\u30f3\u306f\u3001\u30d1\u30fc\u30c8\u30ca\u30fc\u4f01\u696d\u304c\u7fa9\u52d9\u3092\u679c\u305f\u3059\u3053\u3068\u3092\u78ba\u7d04\u3067\u304d\u307e\u305b\u3093\u3002 \u307e\u305f\u3001\u3053\u308c\u3089\u306e\u5951\u7d04\u304b\u3089\u4f55\u306e\u5229\u76ca\u3082\u5f97\u3089\u308c\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30d7\u30bb\u30f3\u306e\u30d1\u30fc\u30c8\u30ca\u30fc\u4f01\u696d\u306e\u3044\u305a\u308c\u304b\u304c\u50b5\u52d9\u4e0d\u5c65\u884c\u306b\u9665\u3063\u305f\u5834\u5408\u3001\u4e88\u60f3\u3092\u4e0b\u56de\u308b\u53ce\u76ca\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u72b6\u6cc1\u306f\u3001\u30a4\u30d7\u30bb\u30f3\u306e\u4e8b\u696d\u3001\u8ca1\u52d9\u72b6\u6cc1\u3001\u696d\u7e3e\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u30a4\u30d7\u30bb\u30f3\u306f\u3001\u9069\u7528\u3055\u308c\u308b\u6cd5\u4ee4\u306b\u3088\u308a\u8981\u6c42\u3055\u308c\u308b\u5834\u5408\u3092\u9664\u304d\u3001\u672c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u306b\u542b\u307e\u308c\u308b\u5c06\u6765\u306e\u898b\u901a\u3057\u306b\u95a2\u3059\u308b\u8a18\u8ff0\u3001\u76ee\u6a19\u3001\u307e\u305f\u306f\u898b\u7a4d\u3082\u308a\u3092\u3001\u305d\u308c\u3089\u306e\u8a18\u8ff0\u306e\u6839\u62e0\u3068\u306a\u308b\u4e8b\u8c61\u3001\u6761\u4ef6\u3001\u4eee\u5b9a\u3001\u307e\u305f\u306f\u72b6\u6cc1\u306e\u5909\u5316\u306b\u5fdc\u3058\u3066\u66f4\u65b0\u307e\u305f\u306f\u4fee\u6b63\u3059\u308b\u7fa9\u52d9\u307e\u305f\u306f\u7d04\u675f\u3092\u660e\u793a\u7684\u306b\u5426\u8a8d\u3057\u307e\u3059\u3002\u30a4\u30d7\u30bb\u30f3\u306e\u4e8b\u696d\u306f\u3001\u30d5\u30e9\u30f3\u30b9\u91d1\u878d\u5e02\u5834\u5e81\uff08Autorit\u00e9 des March\u00e9s Financiers\uff09\u306b\u63d0\u51fa\u3055\u308c\u305f\u767b\u9332\u66f8\u985e\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u30ea\u30b9\u30af\u8981\u56e0\u306e\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002\u3053\u3053\u306b\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u30ea\u30b9\u30af\u304a\u3088\u3073\u4e0d\u78ba\u5b9f\u6027\u306f\u7db2\u7f85\u7684\u306a\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u8aad\u8005\u306fipsen.com \u3067\u5165\u624b\u53ef\u80fd\u306a\u30a4\u30d7\u30bb\u30f3\u306b\u3088\u308b\u6700\u65b0\u306e\u30e6\u30cb\u30d0\u30fc\u30b5\u30eb\u767b\u9332\u66f8\u985e\u3092\u3054\u53c2\u7167\u3044\u305f\u3060\u304f\u3053\u3068\u3092\u63a8\u5968\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-vivid-cyan-blue-color has-text-color has-link-color has-medium-font-size wp-elements-494f15fc1a87749feeef0c6a3f333e4c\">\u53c2\u8003\u6587\u732e<\/p>\n\n\n\n<p class=\"has-small-font-size\">1 https:\/\/www.nanbyou.or.jp\/entry\/22457 \uff082025 \u5e749 \u6708\u30a2\u30af\u30bb\u30b9\uff09<br>2 Agarwal S, et al. Progressive Familial Intrahepatic Cholestasis (PFIC) in Indian Children: Clinical Spectrum and Outcome. J Clin Exp Hepatol. 2016. v.6\uff083\uff09.<br>3 Davit-Spraul A, et al. Progressive familial intrahepatic cholestasis. Orphanet J Rare Dis. 2009. 4\uff081\uff09:1-12.<br>4 Thompson RJ, et al. Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomized, placebocontrolled,phase 3 trial. Lancet Gastroenteterol Hepatol 2022;7:830-842.<br>5 Thompson RJ, et al. Interim results from an ongoing, open-label, single-arm trial of odevixibat in progressive familial intrahepatic cholestasis 2023. JHEP Rep. 5\uff088\uff09:100782.<\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":103,"template":"","categories":[31],"tags":[],"class_list":["post-752","press_release","type-press_release","status-publish","hentry","category-31","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97 - Japan<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97 - Japan\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/\" \/>\n<meta property=\"og:site_name\" content=\"Japan\" \/>\n<meta property=\"article:modified_time\" content=\"2025-11-25T22:01:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/\",\"url\":\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/\",\"name\":\"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97 - Japan\",\"isPartOf\":{\"@id\":\"https:\/\/www.ipsen.com\/japan\/#website\"},\"datePublished\":\"2025-09-19T06:43:48+00:00\",\"dateModified\":\"2025-11-25T22:01:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/#breadcrumb\"},\"inLanguage\":\"ja-JA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.ipsen.com\/japan\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.ipsen.com\/japan\/#website\",\"url\":\"https:\/\/www.ipsen.com\/japan\/\",\"name\":\"Japan\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/www.ipsen.com\/japan\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.ipsen.com\/japan\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja-JA\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.ipsen.com\/japan\/#organization\",\"name\":\"Japan\",\"url\":\"https:\/\/www.ipsen.com\/japan\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ja-JA\",\"@id\":\"https:\/\/www.ipsen.com\/japan\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/sites\/11\/2024\/01\/12064912\/Logo-Ipsen.svg\",\"contentUrl\":\"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/sites\/11\/2024\/01\/12064912\/Logo-Ipsen.svg\",\"caption\":\"Japan\"},\"image\":{\"@id\":\"https:\/\/www.ipsen.com\/japan\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97 - Japan","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/","og_locale":"en_US","og_type":"article","og_title":"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97 - Japan","og_url":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/","og_site_name":"Japan","article_modified_time":"2025-11-25T22:01:48+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/","url":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/","name":"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97 - Japan","isPartOf":{"@id":"https:\/\/www.ipsen.com\/japan\/#website"},"datePublished":"2025-09-19T06:43:48+00:00","dateModified":"2025-11-25T22:01:48+00:00","breadcrumb":{"@id":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/#breadcrumb"},"inLanguage":"ja-JA","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.ipsen.com\/japan\/press-releases\/%e3%83%97%e3%83%ac%e3%82%b9%e3%83%aa%e3%83%aa%e3%83%bc%e3%82%b9\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ipsen.com\/japan\/"},{"@type":"ListItem","position":2,"name":"\u30a4\u30d7\u30bb\u30f3\u3001\u5e0c\u5c11\u809d\u75be\u60a3\u300c\u9032\u884c\u6027\u5bb6\u65cf\u6027\u809d\u5185\u80c6\u6c41\u3046\u3063\u6ede\u75c7\u306b\u4f34\u3046\u305d\u3046\u75d2\u300d\u6cbb\u7642\u85ac\u30d3\u30eb\u30d9\u30a4\u00ae\uff08\u30aa\u30c7\u30d3\u30ad\u30b7\u30d0\u30c3\u30c8\uff09\u306e\u65e5\u672c\u306b\u304a\u3051\u308b\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u53d6\u5f97"}]},{"@type":"WebSite","@id":"https:\/\/www.ipsen.com\/japan\/#website","url":"https:\/\/www.ipsen.com\/japan\/","name":"Japan","description":"","publisher":{"@id":"https:\/\/www.ipsen.com\/japan\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ipsen.com\/japan\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja-JA"},{"@type":"Organization","@id":"https:\/\/www.ipsen.com\/japan\/#organization","name":"Japan","url":"https:\/\/www.ipsen.com\/japan\/","logo":{"@type":"ImageObject","inLanguage":"ja-JA","@id":"https:\/\/www.ipsen.com\/japan\/#\/schema\/logo\/image\/","url":"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/sites\/11\/2024\/01\/12064912\/Logo-Ipsen.svg","contentUrl":"https:\/\/www.ipsen.com\/websites\/ipsen_com_v2\/wp-content\/uploads\/sites\/11\/2024\/01\/12064912\/Logo-Ipsen.svg","caption":"Japan"},"image":{"@id":"https:\/\/www.ipsen.com\/japan\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/press_release\/752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/press_release"}],"about":[{"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/types\/press_release"}],"author":[{"embeddable":true,"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/users\/103"}],"version-history":[{"count":33,"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/press_release\/752\/revisions"}],"predecessor-version":[{"id":991,"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/press_release\/752\/revisions\/991"}],"wp:attachment":[{"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/media?parent=752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/categories?post=752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ipsen.com\/japan\/wp-json\/wp\/v2\/tags?post=752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}