{"id":86213,"date":"2025-09-01T10:44:39","date_gmt":"2025-09-01T08:44:39","guid":{"rendered":"https:\/\/www.ipsen.com\/rare-diseases\/au-dela-de-la-fatigue-comprendre-la-fatigue-dans-la-cholangite-biliaire-primitive\/"},"modified":"2025-09-01T11:08:42","modified_gmt":"2025-09-01T09:08:42","slug":"au-dela-de-la-fatigue-comprendre-la-fatigue-dans-la-cholangite-biliaire-primitive","status":"publish","type":"post","link":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/au-dela-de-la-fatigue-comprendre-la-fatigue-dans-la-cholangite-biliaire-primitive\/","title":{"rendered":"Au-del\u00e0 de la fatigue: comprendre la fatigue dans la cholangite biliaire primitive"},"content":{"rendered":"    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash hidden\">\n                <h3 class=\"heading-three\" role=\"heading\" aria-level=\"2\">\n                                            <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <p><em>&#8220;La fatigue est tellement diff\u00e9rente de la fatigue ; je n\u2019arrive pas \u00e0 sortir du lit\u2026 \u00e7a change ma vie.&#8221;<\/em><\/p>\n<p>\u2013 Wendy, atteinte de CBP<\/p>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                \n            <\/div>\n        <\/div>\n    <\/section>\n\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-page_Thumbnail-v1.2.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\" role=\"heading\" aria-level=\"2\">\n                                    Comprendre la fatigue                                <\/h4>\n                                                    <\/div>\n                                                <p>\u2022 La fatigue est une affection distincte et d\u00e9bilitante qui peut avoir un impact significatif sur la qualit\u00e9 de vie<sup>1<br \/>\n<\/sup><br \/>\n\u2022 Elle accompagne souvent des maladies auto-immunes telles que la cholangite biliaire primitive (CBP), le lupus, la scl\u00e9rose en plaques et d\u2019autres maladies inflammatoires chroniques<sup>2<br \/>\n<\/sup><br \/>\n\u2022 Bien que la fatigue puisse souvent \u00eatre soulag\u00e9e par le repos ou le sommeil, la fatigue est une maladie chronique qui n\u2019est pas am\u00e9lior\u00e9e par le repos<sup>1<br \/>\n<\/sup><br \/>\n\u2022 La fatigue est persistante, accablante et disproportionn\u00e9e par rapport \u00e0 l\u2019activit\u00e9. Elle affecte le fonctionnement physique, \u00e9motionnel et mental, interf\u00e9rant souvent avec la vie quotidienne<sup>2<\/sup><\/p>\n                            <a \n                            aria-label=\" about Comprendre la fatigue\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n<!--Graphics Cards Carousel Start Here-->\n\n    <section class=\"graphic-card graphics-new-layout bg-color-disabled bg-image-disabled bg-video-disabled bg-mobile-video-img-disabled\"    data-displaycards=\"3\">\n                <div class=\"container\">\n            <div class=\"text-graph-inner\">\n                <div class=\"row\">\n                    <!--Graphic info section-->\n                    <div class=\"column-1 col-xl-12 col-md-12 col-sm-12\">\n                        <div class=\"text-graph-heading\">\n                        <h3 class=\"charcoal-grey visible heading-three\" role=\"heading\" aria-level=\"2\">\n                                \u00c0 propos de CBP                            <\/h3>\n                            <p class=\"text-graph-para charcoal-grey visible\">La CBP est une maladie h\u00e9patique cholestatique, auto-immune, \u00e9volutive et rare, dont la pr\u00e9valence augmente \u00e0 l\u2019\u00e9chelle mondiale<sup>3<sup><\/p>\n                        <\/div>\n                    <\/div><!--Graphic info section over here -->\n\n                    <!--Graphic detail section-->\n                    <div class=\"column-2 col-xl-12 col-md-12 col-sm-12\">\n                        <!-- graphic-card carousel start here -->\n                                                    <div class=\"text-graph-carousel\">\n                                <div class=\"glider-contain multiple\">\n                                                                                    <div class=\"text-graph-content-btn\">\n                                                    <button aria-hidden=\"true\" aria-label=\"Pr\u00e9c\u00e9dent\" class=\"glider-graphic-card-prev\"><span><\/span><\/button>\n                                                    <button aria-hidden=\"true\" aria-label=\"Suivant\" class=\"glider-graphic-card-next\"><span><\/span><\/button>\n                                                <\/div>\n                                    \n                                <div class=\"glider-graphic-card\" tabindex=\"-1\">\n                                                                                                                        <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\"><\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-30.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Auto-immune signifie que chez les personnes atteintes de CBP, un type de globule blanc pr\u00e9sent dans le corps attaque et d\u00e9truit progressivement les petits canaux biliaires du foie<sup>3<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\"><\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-31.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Les voies biliaires sont de minuscules tubes dans le foie qui aident \u00e0 transporter la bile, un liquide contenant des acides biliaires qui d\u00e9composent les graisses et aident \u00e0 \u00e9liminer les d\u00e9chets du corps<sup>4<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\"><\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-37.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Lorsque les voies biliaires sont endommag\u00e9es, la bile ne peut pas circuler correctement et commence \u00e0 s\u2019accumuler dans le foie, ce qui provoque un stress et des dommages aux cellules h\u00e9patiques<sup>3<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\"><\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-36.png\" alt=\"\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Au fil du temps, le foie se cicatrise (fibrose) et, si la situation continue de s\u2019aggraver, elle peut entra\u00eener une cirrhose (graves l\u00e9sions h\u00e9patiques) et m\u00eame une insuffisance h\u00e9patique<sup>3<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                <\/div>\n                            <\/div>\n                                            <\/div> <!-- graphic-card carousel end here -->\n                <\/div> <!--Graphic detail section over here with 12 grid -->   \n            <\/div><!--row ended here-->\n        <\/div> <!-- graph-inner ended here -->\n        \n            <div class=\"more-result-btn\">\n                                            <\/div>\n        <\/div> <!--Container class ended here -->\n    <\/section>\n<!--Graphics Cards Carousel End Here-->\n\n\n\n<h2 class=\"wp-block-heading\">Les sympt\u00f4mes les plus courants de la CBP<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">    <section class=\"image-card\">\n        <div class=\"container\">\n            <!-- Block Details -->\n            <div class=\"image-card-header\">\n                <h3 class=\"image-card-block-title visible heading-three\">\n                    La fatigue                <\/h3>\n                <p class=\"charcoal-grey image-card-block-summary hidden\"> <\/p>\n            <\/div>\n\n            <!-- Image Desktop\/Image -->                \n                <div class=\"mobile-view\"> \n                                    <\/div>                \n                <div class=\"desktop-view\"> \n                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_Common-Symptoms_Fatigue-v1.png\" alt=\"Desktop Image\" title=\"Desktop Image\">\n                <\/div>\n\n            <!-- Block CTA -->\n            <div class=\"cta-block hidden\">\n                            <\/div>\n\n        <\/div>\n    <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">    <section class=\"image-card\">\n        <div class=\"container\">\n            <!-- Block Details -->\n            <div class=\"image-card-header\">\n                <h3 class=\"image-card-block-title visible heading-three\">\n                    Le prurit (d\u00e9mangeaisons)                <\/h3>\n                <p class=\"charcoal-grey image-card-block-summary hidden\"> <\/p>\n            <\/div>\n\n            <!-- Image Desktop\/Image -->                \n                <div class=\"mobile-view\"> \n                                    <\/div>                \n                <div class=\"desktop-view\"> \n                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_Common-Symptoms_Itch-v1.png\" alt=\"Desktop Image\" title=\"Desktop Image\">\n                <\/div>\n\n            <!-- Block CTA -->\n            <div class=\"cta-block hidden\">\n                            <\/div>\n\n        <\/div>\n    <\/section>\n<\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">La fatigue est un sympt\u00f4me courant et d\u00e9bilitant de la CBP<\/h2>\n\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC_Fatigue-Symptom_Icon-Diagram_v1.3.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\" role=\"heading\" aria-level=\"2\">\n                                    La fatigue touche jusqu\u2019\u00e0 80% des personnes atteintes de CBP                                <\/h4>\n                                                    <\/div>\n                                                    <p class=\"section-head-two heading-para\" role=\"heading\" aria-level=\"3\">\n                                    Et jusqu\u2019\u00e0 20 % d\u2019entre elles souffrent d\u2019une fatigue s\u00e9v\u00e8re.                                <\/p>\n                                                <p>&nbsp;<\/p>\n<p>La fatigue n\u2019est pas simplement un effet secondaire d\u2019autres sympt\u00f4mes tels que le prurit.<\/p>\n<p>Bien que le prurit puisse contribuer \u00e0 l\u2019exp\u00e9rience de la fatigue, les recherches montrent que les deux sympt\u00f4mes ne sont que faiblement corr\u00e9l\u00e9s<sup>7<\/sup>, indiquant que des m\u00e9canismes distincts sont impliqu\u00e9s.<\/p>\n<p>Cela sugg\u00e8re que la fatigue peut s\u2019am\u00e9liorer de mani\u00e8re ind\u00e9pendante gr\u00e2ce \u00e0 une intervention cibl\u00e9e, renfor\u00e7ant ainsi son statut de maladie traitable.<\/p>\n                            <a \n                            aria-label=\" about La fatigue touche jusqu\u2019\u00e0 80% des personnes atteintes de CBP\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner section-reverse\">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row section-reverse\">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC_Measurable_Icon-Diagram_v1.4.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\" role=\"heading\" aria-level=\"2\">\n                                    La fatigue est une condition mesurable                                <\/h4>\n                                                    <\/div>\n                                                    <p class=\"section-head-two heading-para\" role=\"heading\" aria-level=\"3\">\n                                    La fatigue est cliniquement significative dans la CBP                                <\/p>\n                                                <p>La fatigue dans la CBP n\u2019est pas li\u00e9e au stade de la maladie ou \u00e0 l\u2019\u00e9tendue des l\u00e9sions h\u00e9patiques et peut m\u00eame persister apr\u00e8s une transplantation h\u00e9patique.<sup>8<\/sup> Des \u00e9tudes montrent que jusqu\u2019\u00e0 37 % des personnes atteintes de CBP continuent de ressentir de la fatigue apr\u00e8s une transplantation h\u00e9patique, ce qui en fait une affection qui n\u00e9cessite une attention particuli\u00e8re.<sup>9 <\/sup><\/p>\n<p><em>*La fatigue intense est une cause importante d\u2019alt\u00e9ration de la qualit\u00e9 de vie<sup>10<\/sup><\/em><br \/>\n<em> ** La fatigue est \u00e9valu\u00e9e \u00e0 l\u2019aide d\u2019outils valid\u00e9s de r\u00e9sultats rapport\u00e9s par les patients<sup>1<\/sup><\/em><\/p>\n                            <a \n                            aria-label=\" about La fatigue est une condition mesurable\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash hidden\">\n                <h3 class=\"heading-three\" role=\"heading\" aria-level=\"2\">\n                                            <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <p>Bien que la fatigue soit courante chez les personnes atteintes de CBP, il existe d\u00e9sormais des preuves que certains traitements de la CBP peuvent am\u00e9liorer la fatigue.<sup>7,9<\/sup><\/p>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                \n            <\/div>\n        <\/div>\n    <\/section>\n\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_Science-in-Fatigue-v1.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\" role=\"heading\" aria-level=\"2\">\n                                    D\u00e9couvrir la science de la fatigue dans la CBP                                <\/h4>\n                                                    <\/div>\n                                                <p>Des techniques avanc\u00e9es d\u2019imagerie c\u00e9r\u00e9brale montrent des changements dans l\u2019activit\u00e9 c\u00e9r\u00e9brale et la connectivit\u00e9 associ\u00e9s \u00e0 la fatigue chez les personnes atteintes de CBP.<sup>11<br \/>\n<\/sup><\/p>\n<p>Des recherches r\u00e9centes sugg\u00e8rent que la fatigue dans la CBP est li\u00e9e \u00e0 une communication perturb\u00e9e entre les zones c\u00e9r\u00e9brales impliqu\u00e9es dans le contr\u00f4le moteur, le traitement sensoriel et la r\u00e9gulation \u00e9motionnelle.<sup>12<\/sup><\/p>\n                            <a \n                            aria-label=\" about D\u00e9couvrir la science de la fatigue dans la CBP\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n<!--Graphics Cards Carousel Start Here-->\n\n    <section class=\"graphic-card graphics-new-layout bg-color-disabled bg-image-disabled bg-video-disabled bg-mobile-video-img-disabled\"    data-displaycards=\"3\">\n                <div class=\"container\">\n            <div class=\"text-graph-inner\">\n                <div class=\"row\">\n                    <!--Graphic info section-->\n                    <div class=\"column-1 col-xl-12 col-md-12 col-sm-12\">\n                        <div class=\"text-graph-heading\">\n                        <h3 class=\"charcoal-grey visible heading-three\" role=\"heading\" aria-level=\"2\">\n                                Une lutte quotidienne qui touche tous les aspects de la vie                            <\/h3>\n                            <p class=\"text-graph-para charcoal-grey visible\">La fatigue peut avoir une s\u00e9rie d\u2019impacts physiques, \u00e9motionnels et cognitifs qui peuvent perturber profond\u00e9ment la qualit\u00e9 de vie:<\/p>\n                        <\/div>\n                    <\/div><!--Graphic info section over here -->\n\n                    <!--Graphic detail section-->\n                    <div class=\"column-2 col-xl-12 col-md-12 col-sm-12\">\n                        <!-- graphic-card carousel start here -->\n                                                    <div class=\"text-graph-carousel\">\n                                <div class=\"glider-contain multiple\">\n                                                                                    <div class=\"text-graph-content-btn\">\n                                                    <button aria-hidden=\"true\" aria-label=\"Pr\u00e9c\u00e9dent\" class=\"glider-graphic-card-prev\"><span><\/span><\/button>\n                                                    <button aria-hidden=\"true\" aria-label=\"Suivant\" class=\"glider-graphic-card-next\"><span><\/span><\/button>\n                                                <\/div>\n                                    \n                                <div class=\"glider-graphic-card\" tabindex=\"-1\">\n                                                                                                                        <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\">Impact physique<\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-33.png\" alt=\"Impact physique\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Limite les mouvements et les fonctions quotidiennes<sup>12<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\">Impact cognitif<\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-34.png\" alt=\"Impact cognitif\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Perturbe la qualit\u00e9 du sommeil, la m\u00e9moire et la concentration<sup>13<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\">Impact \u00e9motionnel<\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-35.png\" alt=\"Impact \u00e9motionnel\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Anxi\u00e9t\u00e9, d\u00e9pression, isolement<sup>14<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                                                                    <div class=\"text-graphic\">\n                                                    <div class=\"text-graph-row\">\n                                                                                                                       <!-- Graphic Card With NEW layout start here -->\n                                                                <div class=\"column-2\">\n                                                                    <div class=\"left-text-graph-content\">\n                                                                        <div class=\"left-text-graph-title\">\n                                                                        <h5 role=\"heading\" aria-level=\"3\">Impact social<\/h5>\n                                                                        <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-img visible graphic-icon-enabled\">\n                                                                                                                                                                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_New-branding_Icons-29.png\" alt=\"Impact social\" \/> \n                                                                                                                                                            <\/div>\n                                                                                                                                                    <div class=\"left-text-graph-desc\">\n                                                                                <p><p>Relations tendues et difficult\u00e9 \u00e0 conserver un emploi<sup>15<\/sup><\/p>\n<\/p>\n                                                                            <\/div>\n                                                                    <\/div>\n                                                                <\/div>\n                                                                <!-- Graphic Card With NEW layout end here -->\n                                                        \n                                                    <\/div>\n                                                <\/div>\n                                                                                                                <\/div>\n                            <\/div>\n                                            <\/div> <!-- graphic-card carousel end here -->\n                <\/div> <!--Graphic detail section over here with 12 grid -->   \n            <\/div><!--row ended here-->\n        <\/div> <!-- graph-inner ended here -->\n        \n            <div class=\"more-result-btn\">\n                                            <\/div>\n        <\/div> <!--Container class ended here -->\n    <\/section>\n<!--Graphics Cards Carousel End Here-->\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Jusqu\u2019\u00e0 55 % des personnes atteintes de CBP et souffrant de fatigue s\u00e9v\u00e8re pr\u00e9sentent des sympt\u00f4mes cognitifs cliniquement significatifs.<sup>14<\/sup><\/p>\n\n\n    <section class=\"image-card\">\n        <div class=\"container\">\n            <!-- Block Details -->\n            <div class=\"image-card-header\">\n                <h3 class=\"image-card-block-title hidden heading-three\">\n                                    <\/h3>\n                <p class=\"charcoal-grey image-card-block-summary hidden\"> <\/p>\n            <\/div>\n\n            <!-- Image Desktop\/Image -->                \n                <div class=\"mobile-view\"> \n                                    <\/div>                \n                <div class=\"desktop-view\"> \n                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_PBC-Stats_Cognitive-v1.png\" alt=\"Desktop Image\" title=\"Desktop Image\">\n                <\/div>\n\n            <!-- Block CTA -->\n            <div class=\"cta-block hidden\">\n                            <\/div>\n\n        <\/div>\n    <\/section>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<p>Moins de 20 % des personnes atteintes de CBP et souffrant de fatigue s\u00e9v\u00e8re sont capables de travailler.<sup>16<\/sup><\/p>\n\n\n    <section class=\"image-card\">\n        <div class=\"container\">\n            <!-- Block Details -->\n            <div class=\"image-card-header\">\n                <h3 class=\"image-card-block-title hidden heading-three\">\n                                    <\/h3>\n                <p class=\"charcoal-grey image-card-block-summary hidden\"> <\/p>\n            <\/div>\n\n            <!-- Image Desktop\/Image -->                \n                <div class=\"mobile-view\"> \n                                    <\/div>                \n                <div class=\"desktop-view\"> \n                    <img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_PBC-Stats_Work-v1.png\" alt=\"Desktop Image\" title=\"Desktop Image\">\n                <\/div>\n\n            <!-- Block CTA -->\n            <div class=\"cta-block hidden\">\n                            <\/div>\n\n        <\/div>\n    <\/section>\n<\/div>\n<\/div>\n\n\n    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash hidden\">\n                <h3 class=\"heading-three\" role=\"heading\" aria-level=\"2\">\n                                            <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <p><em>&#8220;Parfois, il est difficile de passer une journ\u00e9e au travail\u2026 et cela a un impact sur votre vie sociale\u2026 m\u00eame parler peut-\u00eatre un effort lorsque vous luttez contre la fatigue.&#8221;<\/em><\/p>\n<p>\u2013 Jo, vivant avec la CBP<\/p>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                \n            <\/div>\n        <\/div>\n    <\/section>\n\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_Family-Stress-v1.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\" role=\"heading\" aria-level=\"2\">\n                                    Les cons\u00e9quences profondes de la fatigue                                <\/h4>\n                                                    <\/div>\n                                                <p>La fatigue n\u2019est pas seulement un sympt\u00f4me : c\u2019est un fardeau global et de grande port\u00e9e qui a des r\u00e9percussions qui s\u2019\u00e9tendent bien au-del\u00e0 de l\u2019individu.<\/p>\n<p>Cela transf\u00e8re souvent les responsabilit\u00e9s quotidiennes sur la famille et les soignants, ce qui entra\u00eene une d\u00e9tresse \u00e9motionnelle et des difficult\u00e9s financi\u00e8res.<sup>16,17<\/sup><\/p>\n<p>Cela peut \u00e9galement contribuer \u00e0 une r\u00e9duction de la participation au march\u00e9 du travail et \u00e0 une retraite anticip\u00e9e.<sup>18,19<\/sup><\/p>\n                            <a \n                            aria-label=\" about Les cons\u00e9quences profondes de la fatigue\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner section-reverse\">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row section-reverse\">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_Work-productivity-v1.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                    <\/div>\n                                                    <p class=\"section-head-two heading-para\" role=\"heading\" aria-level=\"3\">\n                                    Jusqu\u2019\u00e0 60 % des personnes atteintes de CBP signalent une perte de productivit\u00e9                                 <\/p>\n                                                <p>\u00c0 mesure que les sympt\u00f4mes progressent, de nombreuses personnes ne peuvent plus se permettre les soins n\u00e9cessaires pour leurs maladies chroniques ou de longue dur\u00e9e, comme la CBP. Ceci peut amener les proches \u00e0 fournir des soins gratuits, ce qui peut entra\u00eener une perte d\u2019emploi et de salaire.<sup>17,18<\/sup><\/p>\n                            <a \n                            aria-label=\" about \"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n<!-- Text & Media Block Code -->\n<section class=\"two-col-section text-media-section\">\n    <div class=\"container two-section-innner \">\n        <div class=\"response-inner\" style=\"background-image: url('')\">\n            <div class=\"row \">\n                <div class=\"col-xs-12 col-sm-12 col-md-6\">\n                                                    <div class=\"img-video-section\">\n                                <img decoding=\"async\" \n                                    src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Ipsen_PBC-Page_Unaddressed-v1.png\" \n                                    alt=\"\" \n                                >\n                            <\/div>\n                                        <\/div>\n                <div class=\" col-xs-12 col-sm-12 col-md-6\">\n                    <div class=\"section-content\">\n                        <div class=\"heading-dash\">\n                                                            <span class=\"dash\"><\/span>\n                                <h4 class=\"heading-para heading-four\" role=\"heading\" aria-level=\"2\">\n                                    La fatigue reste sans r\u00e9ponse                                <\/h4>\n                                                    <\/div>\n                                                <p>Malgr\u00e9 sa pr\u00e9valence et son impact, la fatigue reste mal g\u00e9r\u00e9e et souvent n\u00e9glig\u00e9e dans les soins cliniques.<sup>8<\/sup><\/p>\n<p>Bien qu\u2019il existe des outils valid\u00e9s et des seuils cliniques pour suivre la fatigue, ils ne sont pas syst\u00e9matiquement mis en \u0153uvre dans la pratique,20 ce qui entra\u00eene des occasions manqu\u00e9es de gestion.<\/p>\n                            <a \n                            aria-label=\" about La fatigue reste sans r\u00e9ponse\"  \n                                role=\"link\" \n                                class=\"btn-link hidden\"\n                                href=\"\" \n                                target=\"_self\"\n                            > \n                                 \n                            <\/a>\n\n                    <\/div>\n                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash visible\">\n                <h3 class=\"heading-three\" role=\"heading\" aria-level=\"2\">\n                        Nouvelle \u00e8re dans la gestion de la fatigue de la CBP                    <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <p>Il existe un besoin crucial d\u2019am\u00e9liorer la reconnaissance, la mesure de routine et la communication ouverte autour de la fatigue dans la CBP, non seulement en tant que sympt\u00f4me, mais en tant que condition fondamentale qui a un impact significatif sur la qualit\u00e9 de vie.<\/p>\n<p>Le traitement doit aller au-del\u00e0 de la biochimie du foie et s\u2019attaquer \u00e0 la fois \u00e0 la progression de la maladie et au fardeau des sympt\u00f4mes, comme la fatigue. Les professionnels de la sant\u00e9 doivent voir et traiter la personne dans son ensemble, et pas seulement la maladie du foie.<\/p>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                                        <div class=\"btn-txt\">\n                            <a \n                                aria-label=\"\" \n                                class=\"btn-link section-btn cta-visible\"  \n                                role=\"link\"\n                                href=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2025\/09\/Comms_PBC_PBC-Fatigue-Fact-Sheet-designed_August-2025_FRENCH.pdf\" target=\"_blank\">\n                                T\u00e9l\u00e9chargez ici la fiche d&#8217;information                            <\/a>\n                        <\/div>\n                \n            <\/div>\n        <\/div>\n    <\/section>\n\n\n\n    <!--Accordion Cards Start Here-->\n    <section class=\"accordion bg-color-disabled\"  data-according-id=\"1370505980\">\n        <div class=\"container\">\n            <div class=\"row\">\n                <!--Accordion info section-->\n                <div class=\"column-1 col-xl-12 col-md-12 col-sm-12\">\n                    <div class=\"accordian-info\">\n                        <h3 class=\"accordian-heading hidden heading-three\" role=\"heading\" aria-level=\"2\">\n                                                    <\/h3>\n                        <p class=\"accordian-summary hidden\"><\/p>\n                    <\/div>\n                <\/div><!--Accordion info section over here -->\n\n                <div class=\"col-xl-12 col-lg-12 col-md-12 col-sm-12\">\n                    <div class=\"accordion accor-group\" id=\"accordionExample1370505980\">\n                         \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p  role=\"heading\" aria-level=\"3\" class=\"accordion-header accor-head-para\" id=\"faqHeading0\">\n                                            <button class=\"accordion-button accor-faq-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#faqHeading13705059800\" aria-expanded=\"false\" aria-controls=\"faqHeading13705059800\">\n                                                R\u00e9ferences                                            <\/button>\n                                        <\/p>\n                                        <div id=\"faqHeading13705059800\" class=\"accordion-collapse collapse \" aria-labelledby=\"faqHeading0\" data-bs-parent=\"#accordionExample1370505980\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><ol>\n<li>Younossi et al. 2024 Assessment of fatigue and its impact in chronic liver disease. J Hepatol. 81(1 ), pp. 123\u2013134.<\/li>\n<li>Morris et al. 2015. Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses. Neurosci Biobehav Rev. 52, pp. 58\u201392.<\/li>\n<li>Galoosian A, et al. 2020. Clinical updates in primary biliary cholangitis: trends, epidemiology, diagnostics, and new therapeutic approaches. J Clin Transl Hepatol. 8(1),<br \/>\npp. 49-60<\/li>\n<li>Ahmed 2022. Functional, Diagnostic and Therapeutic Aspects of Bile.105-120.<\/li>\n<li>Chalifoux SL, et al. 2017. Extrahepatic Manifestations of Primary Biliary Cholangitis. Gut. 15;11(6 ):771-780.<\/li>\n<li>Jopson, L and Jones, D. 2015. Fatigue in Primary Biliary Cirrhosis: Prevalence, Pathogenesis and Management. Dig Dis. Suppl 2:109-14<\/li>\n<li>Jones et al., Elafibranor improves fatigue versus placebo in patients with primary biliary cholangitis, with limited correlation with pruritus: Analyses from the phase III EL ATIVE\u00ae trial. Poster presented at the EASL Congress May 2025.<\/li>\n<li>Toussaint, A, et al. 2022. Factors associated with severity and persistence of fatigue in patients with primary biliary cholangitis: study protocol of a prospective cohort study with a mixed-methods approach. BMJ open. 12(12): e061419.<\/li>\n<li>Shahini and Ahmed, 2021. Chronic fatigue should not be overlooked in primary biliary cholangitis<\/li>\n<li>Lynch et al. 2022. Understanding fatigue in primary biliary cholangitis. World Journal of Hepatology. 14(6 );111.<\/li>\n<li>Hirschfield et al 2018. The British Society of Gastroenterology\/UK-PBC primary biliary cholangitis treatment and management guidelines. Gut. 67(9 ), pp. 1568\u20131594.<\/li>\n<li>Mosher, VA, et al. 2017. Primary biliary cholangitis alters functional connections of the brain\u2019s deep gray matter. Clinical and translational gastroenterology. 8(7 ):e107.<\/li>\n<li>Maetzler, W, et al. 2024. Fatigue-related changes of daily function: Most promising measures for the digital age. Digital Biomarkers. 8(1 ), 30-39.<\/li>\n<li>Phaw et al. 2021. Understanding Fatigue in Primary Biliary Cholangitis. Clin Liver Dis (Hoboken). 18(2 ), pp. 47\u201351.<\/li>\n<li>Gungabissoon U, et al. 2022. Disease burden of primary biliary cholangitis and associated pruritus based on a cross-sectional US claims analysis. BMJ Open<br \/>\nGastroenterol. 9(1 ), p.e000857.<\/li>\n<li>Khanna et al. 2018. Rituximab for the treatment of fatigue in primary biliary cholangitis (formerly primary biliary cirrhosis): a randomised controlled trial. J Hepatol.<br \/>\n69(5 ), pp. 946\u2013953.<\/li>\n<li>Luk KM, et al. 2020. The Annual Direct and Indirect Health Care Costs for Patients with Chronic Pruritus and their Determining Factors. J Invest Dermatol. 140:699-701 e5.<\/li>\n<li>Statistics OfN. Unpaid care, England and Wales: Census 2021. Available at: https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/healthandwellbeing\/bulletins\/unpaidcareenglandandwales\/census2021. Accessed August 2025.<\/li>\n<li>C Levy, et al. 2023. Understanding the Experience of Patients with Primary Biliary Cholangitis and Pruritus. Abstract presented at ISPOR, 7-11 May 2023, Boston.<\/li>\n<li>\u00a0Parikh-Patel, A, et al. 2002. Functional status of patients with primary biliary cirrhosis. Official journal of the American College of Gastroenterology. 97(11): 2871-2879.<\/li>\n<li>\u00a0Freer A, et al 2024. A home-based exercise programme attenuates fatigue in primary biliary cholangitis: Results from the EXCITED clinical trial. JHEP Reports.<br \/>\n6(12):101210.<\/li>\n<\/ol>\n<\/p>\n                                                    <div class=\"cta-block hidden\" >\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                                                <\/div>\n                <\/div> \n            <\/div>\n        <\/div>\n    <\/section>\n    <!--Accordion Cards End Here-->\n","protected":false},"excerpt":{"rendered":"<p>Les sympt\u00f4mes les plus courants de la CBP La fatigue est un sympt\u00f4me courant et d\u00e9bilitant de la CBP Jusqu\u2019\u00e0<\/p>\n","protected":false},"author":97,"featured_media":86220,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1192,1192],"tags":[],"class_list":{"0":"post-86213","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","6":"hentry","7":"category-rare-diseases-fr","9":"entry"},"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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