{"id":114015,"date":"2026-10-01T14:09:44","date_gmt":"2026-10-01T12:09:44","guid":{"rendered":"https:\/\/www.ipsen.com\/?p=114015"},"modified":"2026-10-01T14:22:18","modified_gmt":"2026-10-01T12:22:18","slug":"pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses","status":"publish","type":"post","link":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/","title":{"rendered":"PFIC chez l&#8217;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0"},"content":{"rendered":"\n<ul class=\"wp-block-list\">\n<li><strong>Un diagnostic cach\u00e9 :<\/strong> Bien que le cholestase intrah\u00e9patique familiale progressive (PFIC) soit largement consid\u00e9r\u00e9 comme une affection infantile, certaines personnes ne pr\u00e9sentent pas de sympt\u00f4mes reconnaissables avant l&#8217;\u00e2ge adulte, ce qui laisse beaucoup de personnes non diagnostiqu\u00e9es ou mal diagnostiqu\u00e9es pendant des ann\u00e9es\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Le co\u00fbt d&#8217;une reconnaissance manqu\u00e9e :<\/strong> Pendant que les adultes cherchent des r\u00e9ponses, les l\u00e9sions h\u00e9patiques peuvent continuer \u00e0 progresser silencieusement, parall\u00e8lement \u00e0 l&#8217;impact physique et \u00e9motionnel de sympt\u00f4mes tels que les d\u00e9mangeaisons, la fatigue et l&#8217;incertitude\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Personne ne devrait naviguer seul avec le PFIC :<\/strong> gr\u00e2ce \u00e0 des initiatives comme PFIC Colors, d\u00e9velopp\u00e9es avec le r\u00e9seau PFIC, nous aidons les gens \u00e0 mieux comprendre le PFIC, \u00e0 se connecter avec un soutien de confiance et \u00e0 se sentir habilit\u00e9s \u00e0 chercher des r\u00e9ponses et des soins sp\u00e9cialis\u00e9s\u00a0<\/li>\n<\/ul>\n\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Qu&#8217;est-ce que le FPIC adulte ?<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Le PFIC est un groupe de <strong>maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares<\/strong> qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l&#8217;absorption des graisses, ainsi qu&#8217;\u00e0 l&#8217;\u00e9limination des d\u00e9chets. <sup>1\u20135<\/sup> Lorsque la bile s&#8217;accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. <sup>1<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Bien que le PFIC soit souvent associ\u00e9 \u00e0 l&#8217;enfance, il est de plus en plus reconnu qu&#8217;il peut aussi se manifester chez l&#8217;adulte. <sup>3,6<\/sup> Dans ces cas, les sympt\u00f4mes peuvent ne pas appara\u00eetre avant plus tard dans la vie, parfois d\u00e9clench\u00e9s par des \u00e9v\u00e9nements tels que la grossesse ou une infection. <sup>2,6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Pour beaucoup, cela signifie des ann\u00e9es de sympt\u00f4mes inexpliqu\u00e9s, de rendez-vous m\u00e9dicaux r\u00e9p\u00e9t\u00e9s et d&#8217;incertitudes avant que la cause sous-jacente ne soit identifi\u00e9e. <sup>6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Quel est l&#8217;impact du PFIC ?<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Pour les adultes vivant avec la PFIC, cette condition peut affecter presque tous les aspects de la vie, de la sant\u00e9 physique et le bien-\u00eatre \u00e9motionnel au travail, aux relations et aux projets d&#8217;avenir. <sup>6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Les sympt\u00f4mes courants<\/strong> incluent des d\u00e9mangeaisons (pruritus), un jaunissement de la peau et des yeux (jaunisse), des douleurs abdominales, de la diarrh\u00e9e et de la fatigue, qui peuvent perturber les activit\u00e9s quotidiennes et la qualit\u00e9 de vie. <sup>7,8<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Pour beaucoup, le sympt\u00f4me le plus difficile est la <strong>d\u00e9mangeaison persistante et<\/strong> invalidante. Comme les d\u00e9mangeaisons ne pr\u00e9sentent aucun signe visible, sa gravit\u00e9 est souvent sous-estim\u00e9e, rendant difficile pour les autres de comprendre ce fardeau \u00e9puisant et d\u00e9vorant, qui peut aller bien au-del\u00e0 des sympt\u00f4mes physiques. <sup>1,6,9,10<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Une d\u00e9mangeaison s\u00e9v\u00e8re peut affecter la concentration, le travail, l&#8217;\u00e9ducation, la vie de famille, les relations et le bien-\u00eatre mental. Les perturbations du sommeil caus\u00e9es par des d\u00e9mangeaisons persistantes peuvent \u00e9puiser les personnes pendant la journ\u00e9e, tandis que l&#8217;impr\u00e9visibilit\u00e9 des sympt\u00f4mes et leur cause sous-jacente peut \u00e9galement cr\u00e9er de l&#8217;anxi\u00e9t\u00e9 quant \u00e0 l&#8217;avenir. <sup>1,10\u201313\u00a0<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Beaucoup de personnes d\u00e9crivent se sentir isol\u00e9es, notamment parce que le PFIC est rare et mal compris par les autres. <sup>6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">De plus, le PFIC est une <strong>affection progressive<\/strong>, ce qui signifie qu&#8217;elle peut \u00e9voluer avec le temps. L&#8217;un des d\u00e9fis de la maladie est que les modifications sous-jacentes du foie peuvent persister m\u00eame lorsque les sympt\u00f4mes fluctuent ou semblent g\u00e9rables. En cons\u00e9quence, les individus peuvent se sentir relativement bien tant que la maladie reste active sous la surface. <sup>6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Sans soins appropri\u00e9s, la bile continue de s&#8217;accumuler dans le foie, ce qui peut causer des dommages \u00e0 long terme et peut finalement entra\u00eener une insuffisance h\u00e9patique. <sup>1,6,14<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Pourquoi un diagnostic de PFIC adulte est-il si difficile ?\u00a0<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Le PFIC chez l&#8217;adulte est souvent mal diagnostiqu\u00e9 ou bien plus tard qu&#8217;il ne devrait l&#8217;\u00eatre. Cela est principalement motiv\u00e9 par <strong>une sensibilisation et une<\/strong> compr\u00e9hension limit\u00e9es chez les adultes. <sup>6,13<\/sup> La perception de longue date du PFIC comme condition infantile peut signifier que les professionnels de sant\u00e9 ne le soup\u00e7onnent pas imm\u00e9diatement chez les adultes. <sup>6,14<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Ce probl\u00e8me contribue au fait que la maladie se manifeste rarement de mani\u00e8re simple ou pr\u00e9visible. Certains adultes peuvent pr\u00e9senter des sympt\u00f4mes l\u00e9gers ou pas apparents. <sup>6,15<\/sup> Pour ceux qui pr\u00e9sentent des sympt\u00f4mes, ils se recoupent souvent avec ceux d&#8217;autres affections plus courantes. <sup>6<\/sup> Dans certains cas, les sympt\u00f4mes vont et viennent au fil du temps,6 rendant difficile l&#8217;identification de la cause sous-jacente.\u00a0\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">En cons\u00e9quence, le PFIC est souvent n\u00e9glig\u00e9, ignor\u00e9 ou attribu\u00e9 \u00e0 d&#8217;autres causes,<sup>6,13<\/sup> <sup><\/sup>ce qui peut laisser les gens frustr\u00e9s et sans soutien. En effet, de nombreux adultes atteints de PFIC passent des ann\u00e9es, voire des d\u00e9cennies, \u00e0 chercher des r\u00e9ponses, ne g\u00e9rant souvent que les sympt\u00f4mes sans soins optimaux \u2013 tandis que les l\u00e9sions h\u00e9patiques peuvent continuer \u00e0 progresser. <sup>6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Comment pouvons-nous combler le foss\u00e9 diagnostique dans le PFIC ?<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Une reconnaissance plus pr\u00e9coce est essentielle pour modifier la trajectoire de la maladie et am\u00e9liorer les r\u00e9sultats \u00e0 long terme chez les adultes atteints de PFIC. <sup>16,17<\/sup> <strong>La premi\u00e8re \u00e9tape consiste \u00e0 accro\u00eetre la sensibilisation<\/strong> \u00e0 la PFIC chez les adultes, afin que les sympt\u00f4mes soient reconnus plus t\u00f4t dans ce contexte et que des tests appropri\u00e9s puissent \u00eatre effectu\u00e9s. <sup>6<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Lorsque le PFIC est suspect\u00e9, <strong>un test g\u00e9n\u00e9tique<\/strong> est souvent utilis\u00e9 pour confirmer le diagnostic. <sup>16,17<\/sup> Parce que la maladie est caus\u00e9e par des modifications de certains g\u00e8nes, le test g\u00e9n\u00e9tique peut identifier la cause sous-jacente. Cependant, les variantes g\u00e9n\u00e9tiques ne sont pas toujours identifi\u00e9es. <sup>18,19<\/sup> Dans certains cas, un diagnostic est finalement pos\u00e9 par une \u00e9valuation clinique compl\u00e8te et l&#8217;exclusion de toutes les autres causes possibles. <sup>18,19<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Un diagnostic confirm\u00e9 peut \u00eatre un tournant important<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Pour certaines personnes, recevoir enfin un diagnostic offre une validation tant attendue que leurs sympt\u00f4mes ont une cause sous-jacente r\u00e9elle. Cela peut \u00e9galement ouvrir la porte \u00e0 des soins sp\u00e9cialis\u00e9s et \u00e0 un acc\u00e8s \u00e0 une communaut\u00e9 solidaire. <sup>17<\/sup>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Quand faut-il envisager le PFIC ?<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Le PFIC pourrait-il \u00eatre l&#8217;explication manquante ? Les adultes pr\u00e9sentant les sympt\u00f4mes ou exp\u00e9riences suivants pourraient b\u00e9n\u00e9ficier d&#8217;une discussion avec un sp\u00e9cialiste du foie : <sup>3,6,17,19<\/sup>\u00a0<\/p>\n\n\n<ul class=\"wp-block-list\">\n<li>D\u00e9mangeaisons persistantes ou r\u00e9currentes inexpliqu\u00e9es\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cholestase ou anomalies inexpliqu\u00e9es dans les tests h\u00e9patiques\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u00c9pisodes de jaunisse\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ant\u00e9c\u00e9dents familiaux de maladie du foie\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Des sympt\u00f4mes rest\u00e9s inexpliqu\u00e9s malgr\u00e9 des recherches ant\u00e9rieures\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Probl\u00e8mes h\u00e9patiques persistants sans cause claire\u00a0<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ant\u00e9c\u00e9dents de cholestase intrah\u00e9patique s\u00e9v\u00e8re ou r\u00e9currente de la grossesse\u00a0<\/li>\n<\/ul>\n\n\n\n<!--Alert Card Layout Start Here-->\n<section class=\"alertcard-section\">\n      <div class=\"container\">\n        <!--Alert Box HTML Start Here-->\n        <div class=\"alert-box info-box\">\n                  <div class=\"info-contents\">\n                            <h4 role=\"heading\" aria-level=\"2\" class=\"info-head heading-four heading-four\">\n                    Comment Ipsen soutient la communaut\u00e9 PFIC                 <\/h4>\n                                      <div class=\"alert-content visible\">\n                  <p><span data-contrast=\"auto\">Chez Ipsen, nous reconnaissons que pour de nombreux adultes vivant avec la PFIC, obtenir un diagnostic peut \u00eatre un moment d\u00e9terminant. Au-del\u00e0 de l&#8217;avancement de la science, nous nous engageons \u00e0 \u00e9couter les exp\u00e9riences des personnes vivant avec des maladies h\u00e9patiques chol\u00e9statiques rares et \u00e0 sensibiliser aux d\u00e9fis auxquels elles sont confront\u00e9es.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Gr\u00e2ce \u00e0 la collaboration avec les organisations de patients et la communaut\u00e9 plus large des maladies rares, nous visons \u00e0 soutenir une reconnaissance pr\u00e9coce, \u00e0 am\u00e9liorer la compr\u00e9hension et \u00e0 aider les individus \u00e0 acc\u00e9der aux soins dont ils ont besoin.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Pour aider \u00e0 comprendre la complexit\u00e9 du PFIC, nous nous sommes associ\u00e9s au r\u00e9seau PFIC pour co-cr\u00e9er la campagne PFIC Colors. Cette initiative organise l&#8217;information en six domaines th\u00e9matiques cod\u00e9s par couleur, offrant un cadre de navigation clair pour aider les familles \u00e0 comprendre l&#8217;ensemble du parcours du PFIC. <\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Cette ann\u00e9e, via notre plateforme PFIC Colors, Ipsen soutient la campagne de la Journ\u00e9e de sensibilisation communautaire PFIC, \u00ab Voir l&#8217;ensemble du tableau \u00bb, en mettant l&#8217;accent sur la population adulte souvent n\u00e9glig\u00e9e du PFIC. Nous encourageons \u00e9galement l&#8217;engagement avec les histoires de la communaut\u00e9 PFIC, qui seront partag\u00e9es sur les r\u00e9seaux sociaux.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">En refl\u00e9tant ces exp\u00e9riences v\u00e9cues diverses, nous contribuons \u00e0 garantir que les familles re\u00e7oivent un soutien significatif tout au long de leur exp\u00e9rience \u2013 depuis le diagnostic.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n              <\/div>\n          <\/div>\n        <\/div>\n        <!--Alert Box HTML Start Here-->\n      <\/div>\n    <\/section>\n<!--Alert Card Layout End Here-->\n\n\n\n    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash visible\">\n                <h3 class=\"heading-three\" role=\"heading\" aria-level=\"2\">\n                        Ressources                    <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"11\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">D\u00e9couvrez le cadre cod\u00e9 par couleur : <\/span><\/b><span data-contrast=\"auto\">Visitez notre hub de campagne <\/span><a href=\"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/couleurs-pfic-comprendre-le-pfic-grace-au-reseau-pfic\/\"><i><span data-contrast=\"auto\">PFIC Couleurs : Comprendre le PFIC avec le r\u00e9seau PFIC<\/span><\/i><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"11\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Acc\u00e9dez au soutien communautaire : <\/span><\/b><span data-contrast=\"auto\">Visitez <\/span><a href=\"https:\/\/www.pfic.org\/learn-about-pfic-disease\/adult-diagnosis-transition-to-adult-care\/\"><span data-contrast=\"auto\">PFIC.org<\/span><\/a><span data-contrast=\"auto\"> pour des ressources fiables, d\u00e9velopp\u00e9es par la communaut\u00e9, ainsi que des liens pour les personnes vivant avec le PFIC<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/li>\n<\/ul>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                \n            <\/div>\n        <\/div>\n    <\/section>\n\n\n\n    <!--Accordion Cards Start Here-->\n    <section class=\"accordion \"  data-according-id=\"1616477938\">        \n        <div class=\"container\">\n            <div class=\"row\">\n                <!--Accordion info section-->\n                <div class=\"column-1 col-xl-12 col-md-12 col-sm-12\">\n                    <div class=\"accordian-info\">\n                        <h3 class=\"accordian-heading visible heading-three\" role=\"heading\" aria-level=\"2\">\n                            Questions-R\u00e9ponses                         <\/h3>\n                        <p class=\"accordian-summary hidden\"><\/p>\n                    <\/div>\n                <\/div><!--Accordion info section over here -->\n\n                <div class=\"col-xl-12 col-lg-12 col-md-12 col-sm-12\">\n                    <div class=\"accordion accor-group\" id=\"accordionExample1616477938\">\n                         \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p  role=\"heading\" aria-level=\"3\" class=\"accordion-header accor-head-para\" id=\"expHeading0\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading16164779380\" aria-expanded=\"false\" aria-controls=\"expHeading16164779380\">\n                                                Quels signes ou sympt\u00f4mes pourraient \u00eatre associ\u00e9s au PFIC chez l&#8217;adulte et pourraient inciter \u00e0 une investigation m\u00e9dicale plus approfondie ?                                             <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading16164779380\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading0\" data-bs-parent=\"#accordionExample1616477938\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><span data-contrast=\"auto\">Certains adultes atteints de PFIC peuvent pr\u00e9senter des sympt\u00f4mes l\u00e9gers ou des sympt\u00f4mes qui vont et viennent, ce qui rend la condition difficile \u00e0 reconna\u00eetre.<\/span><sup><span data-contrast=\"auto\">6 <\/span><\/sup><span data-contrast=\"auto\">Un ant\u00e9c\u00e9dent de probl\u00e8mes inexpliqu\u00e9s de flux biliaire, de jaunisse ou de d\u00e9mangeaisons s\u00e9v\u00e8res et persistantes peut \u00eatre associ\u00e9 \u00e0 la PFIC et pourrait entra\u00eener une \u00e9valuation m\u00e9dicale suppl\u00e9mentaire.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Si vous \u00eates pr\u00e9occup\u00e9 par votre sant\u00e9 ou pensez avoir une PFIC, veuillez consulter votre m\u00e9decin ou un autre professionnel de sant\u00e9 qualifi\u00e9.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n                                                    <div class=\"cta-block hidden\" style=\"text-align: left;\">\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p  role=\"heading\" aria-level=\"3\" class=\"accordion-header accor-head-para\" id=\"expHeading1\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading16164779381\" aria-expanded=\"false\" aria-controls=\"expHeading16164779381\">\n                                                Pourquoi les tests g\u00e9n\u00e9tiques sont-ils si importants ?                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading16164779381\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading1\" data-bs-parent=\"#accordionExample1616477938\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><span data-contrast=\"auto\">Comme les sympt\u00f4mes du PFIC peuvent \u00eatre similaires \u00e0 ceux d&#8217;autres affections h\u00e9patiques, les sympt\u00f4mes seuls ne suffisent souvent pas \u00e0 confirmer un diagnostic.<\/span><span data-contrast=\"auto\"><sup>6<\/sup> <\/span><span data-contrast=\"auto\">Le test g\u00e9n\u00e9tique recherche les changements g\u00e9n\u00e9tiques connus pour causer la PFIC. Identifier un variant g\u00e9n\u00e9tique sp\u00e9cifique aide les \u00e9quipes de sant\u00e9 \u00e0 adapter le plan de soins le plus appropri\u00e9, car certaines options de prise en main peuvent \u00eatre guid\u00e9es par des r\u00e9sultats g\u00e9n\u00e9tiques sp\u00e9cifiques. Cependant, m\u00eame si un test ne d\u00e9tecte pas de variant connu, un diagnostic de PFIC peut tout de m\u00eame \u00eatre pos\u00e9 en excluant toutes les autres causes possibles.<\/span><sup><span data-contrast=\"auto\">17,19<\/span><\/sup><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n                                                    <div class=\"cta-block hidden\" style=\"text-align: left;\">\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p  role=\"heading\" aria-level=\"3\" class=\"accordion-header accor-head-para\" id=\"expHeading2\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading16164779382\" aria-expanded=\"false\" aria-controls=\"expHeading16164779382\">\n                                                Que signifie un r\u00e9sultat non concluant d&#8217;un test g\u00e9n\u00e9tique ?                                             <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading16164779382\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading2\" data-bs-parent=\"#accordionExample1616477938\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><span data-contrast=\"auto\">Parce que notre compr\u00e9hension du PFIC progresse tr\u00e8s rapidement, de nouveaux g\u00e8nes sont constamment d\u00e9couverts et de nouvelles m\u00e9thodes de test sont d\u00e9velopp\u00e9es. Si un test g\u00e9n\u00e9tique ne d\u00e9tecte pas de variant g\u00e9n\u00e9tique connu, cela n&#8217;exclut pas n\u00e9cessairement la PFIC ou une autre cause g\u00e9n\u00e9tique. \u00c0 mesure que les connaissances et les m\u00e9thodes de test \u00e9voluent, les r\u00e9sultats des tests g\u00e9n\u00e9tiques peuvent parfois \u00eatre r\u00e9\u00e9valu\u00e9s ou les tests peuvent \u00eatre r\u00e9p\u00e9t\u00e9s. La signification d&#8217;un r\u00e9sultat non concluant d\u00e9pendra des circonstances de la personne et doit \u00eatre discut\u00e9e avec un professionnel de sant\u00e9.<\/span><sup><span data-contrast=\"auto\"> 20<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/sup><\/p>\n<p><span data-contrast=\"auto\">Si vous avez des questions concernant le r\u00e9sultat d&#8217;un test g\u00e9n\u00e9tique, veuillez consulter votre m\u00e9decin ou un autre professionnel de sant\u00e9 qualifi\u00e9.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n                                                    <div class=\"cta-block hidden\" style=\"text-align: left;\">\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                             \n                                    <!-- Accordion with Expandable panel & FAQs -->\n                                    <div class=\"accordion-item accor-item\">\n                                        <p  role=\"heading\" aria-level=\"3\" class=\"accordion-header accor-head-para\" id=\"expHeading3\">\n                                            <button class=\"accordion-button accor-btn collapsed\" type=\"button\" data-bs-toggle=\"collapse\" data-bs-target=\"#expHeading16164779383\" aria-expanded=\"false\" aria-controls=\"expHeading16164779383\">\n                                                O\u00f9 puis-je trouver plus d&#8217;informations et de soutien ?                                            <\/button>\n                                        <\/p>\n                                        <div id=\"expHeading16164779383\" class=\"accordion-collapse collapse \" aria-labelledby=\"expHeading3\" data-bs-parent=\"#accordionExample1616477938\">\n                                            <div class=\"accordion-body\">\n                                                <div class=\"accordion-data\">\n                                                    <p><span data-contrast=\"auto\">Vous n&#8217;\u00eates pas seul. Si vous avez des inqui\u00e9tudes concernant d&#8217;\u00e9ventuels sympt\u00f4mes ou des questions concernant la PFIC, votre m\u00e9decin ou votre \u00e9quipe de sant\u00e9 devrait \u00eatre votre premier point de contact. Ils peuvent vous orienter vers des informations appropri\u00e9es et des ressources de soutien.\u00a0<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span data-contrast=\"auto\">Pour obtenir des informations fiables suppl\u00e9mentaires et la possibilit\u00e9 de se connecter avec d&#8217;autres personnes concern\u00e9es par le PFIC, visitez <\/span><b><span data-contrast=\"auto\">le R\u00e9seau PPIC. <\/span><\/b><span data-contrast=\"auto\">L&#8217;organisation fournit des ressources, de l&#8217;\u00e9ducation et du soutien aux personnes vivant avec le PFIC et \u00e0 leurs familles. Vous pouvez \u00e9galement trouver une organisation locale de PFIC dans votre r\u00e9gion via leur <\/span><a href=\"https:\/\/www.pfic.org\/connect-support\/global-support-pfic-contact-directory\/\"><span data-contrast=\"auto\">Annuaire mondial de soutien.<\/span><\/a><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n                                                    <div class=\"cta-block hidden\" style=\"text-align: left;\">\n                                                                                                            <\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/div>\n                                                <\/div>\n                <\/div> \n            <\/div>\n        <\/div>\n    <\/section>\n    <!--Accordion Cards End Here-->\n\n\n\n<!--Alert Card Layout Start Here-->\n<section class=\"alertcard-section\">\n      <div class=\"container\">\n        <!--Alert Box HTML Start Here-->\n        <div class=\"alert-box general-box\">\n                    <div class=\"info-icon\">\n              <span class=\"info-circle\"><img decoding=\"async\" src=\"https:\/\/www.ipsen.com\/wp-content\/themes\/ipsen-main\/dist\/images\/alert-info-icon.png\" alt=\"information\"\/><\/i>\n            <\/div>\n                    <div class=\"info-contents\">\n                                      <div class=\"alert-content visible\">\n                  <p><span class=\"TextRun SCXW105550763 BCX8\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">Ces<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">informations<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">sont<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> \u00e0 titre <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">\u00e9ducatif<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">uniquement<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> et ne <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">remplacent<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> pas un conseil, <\/span><span class=\"NormalTextRun ContextualSpellingAndGrammarErrorV2Themed SCXW105550763 BCX8\">un diagnostic<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> ou un <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">traitement<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">m\u00e9dical<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\">. <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">Veuillez<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> consulter <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">votre<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">m\u00e9decin<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> ou <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">votre<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> \u00e9quipe de sant\u00e9 <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">si<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> vous <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">avez<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> des questions ou des <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">pr\u00e9occupations<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">concernant<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">votre<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> sant\u00e9 ou la <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW105550763 BCX8\">possibilit\u00e9<\/span><span class=\"NormalTextRun SCXW105550763 BCX8\"> d&#8217;un PFIC.<\/span><\/span><span class=\"EOP Selected SCXW105550763 BCX8\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n              <\/div>\n          <\/div>\n        <\/div>\n        <!--Alert Box HTML Start Here-->\n      <\/div>\n    <\/section>\n<!--Alert Card Layout End Here-->\n\n\n\n    <section class=\"title-text \">\n        <div class=\"container\">\n            <div class=\"title-text-inner\" style=\"background-color:#EDEBE4;\">\n\n                <!-- If heading is enabled then it's visible -->\n                <div class=\"text-head-dash visible\">\n                <h3 class=\"heading-three\" role=\"heading\" aria-level=\"2\">\n                        R\u00e9f\u00e9rences                    <\/h3>\n                <\/div>\n               \n                <!-- If description is enabled then it's visible -->\n                <div class=\"text-parbase visible\">\n                    <p><em><span class=\"cf0\">1. Kamath BM, et al. 2020. Potential of ileal bile acid transporter inhibition as a therapeutic target in Alagille syndrome and progressive familial intrahepatic cholestasis<\/span><span class=\"cf1\">. Liver Int<\/span><span class=\"cf0\">. 40(8):1812\u20131822.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">2. Henkel SA, et al. 2019. Expanding etiology of progressive familial intrahepatic cholestasis. World J Hepatol. 11(5):450\u2013463.\u00a0\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">3. Davit-Spraul A, et al. 2009. Progressive familial intrahepatic cholestasis. <\/span><span class=\"cf1\">Orphanet J Rare Dis<\/span><span class=\"cf0\">. 4:1.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">4. Goldberg A, Mack CL. 2020. Inherited Cholestatic Diseases in the Era of Personalized Medicine. <\/span><span class=\"cf1\">Clin Liver Dis<\/span><span class=\"cf0\"> 15(3):105\u2013109.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">5. van Wessel DBE, et al. 2020. Genotype correlates with the natural history of severe bile salt export pump deficiency. <\/span><span class=\"cf1\">J Hepatol<\/span><span class=\"cf0\">. 73(1):84\u201393.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">6. Berg T. 2024. Progressive Familial Intrahepatic Cholestasis in Adulthood: Genetics, Diagnosis, Treatment, and Further Research. <\/span><span class=\"cf1\">EMJ Hepatol<\/span><span class=\"cf0\">. 12[Suppl 2]:2\u20137.\u202f\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">7. Mehl A, et al. 2016. Liver transplantation and the management of\u00a0\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">progressive familial intrahepatic cholestasis in children. World J\u00a0\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">Transplant. 6(2):278-290.\u00a0\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">8. Halawi A, et al. 2021. Triggers of benign recurrent intrahepatic cholestasis and its pathophysiology: a review of literature. <\/span><span class=\"cf1\">Acta Gastroenterol Belg<\/span><span class=\"cf0\">. 84(3):477\u2013486.<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">9. Patel SP, et al. 2019. Cholestatic pruritus: Emerging mechanisms and therapeutics. <\/span><span class=\"cf1\">J Am Acad Dermatol<\/span><span class=\"cf0\">. 81(6):1371\u20131378.\u00a0\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">10. Brown K. 2025. Update on the Management of Cholestatic Pruritus. <\/span><span class=\"cf1\">Gastroenterol Hepatol<\/span><span class=\"cf0\"> (NY). 21(5):315\u2013317.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">11. Langedijk JAGM, et al. 2021. Cholestasis-Associated Pruritus and Its Pruritogens. <\/span><span class=\"cf1\">Front Med<\/span><span class=\"cf0\"> (Lausanne). 8:639674.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">12. Tajiri K, Shimizu Y. 2017. Recent advances in the management of pruritus in chronic liver diseases. <\/span><span class=\"cf1\">World J Gastroenterol<\/span><span class=\"cf0\">. 23(19):3418\u20133426.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">13. Canadian Agency for Drugs and Technologies in Health. 2024. Odevixibat (Bylvay): CADTH Reimbursement Recommendation: Indication: The treatment of pruritus in patients aged 6 months or older with progressive familial intrahepatic cholestasis [Internet]. Report No.: SR0788. PMID: 38648297.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">14. Baker A, et al. Systematic review of progressive familial intrahepatic cholestasis. 2019. <\/span><span class=\"cf1\">Clin Res Hepatol Gastroenterol<\/span><span class=\"cf0\">. 43(1):20\u201336.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">15. Alam S, Lal BB. 2022. Recent updates on progressive familial intrahepatic cholestasis types 1, 2 and 3: Outcome and therapeutic strategies. <\/span><span class=\"cf1\">World J Hepatol<\/span><span class=\"cf0\">. 14(1):98\u2013118.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">16. McKiernan P, et al. 2023. Opinion paper on the diagnosis and treatment of progressive familial intrahepatic cholestasis. <\/span><span class=\"cf1\">JHEP Rep<\/span><span class=\"cf0\">. 6(1):100949.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">17. Gunaydin M, et al. 2018. Progressive familial intrahepatic cholestasis: diagnosis, management, and treatment<\/span><span class=\"cf1\">. Hepat Med<\/span><span class=\"cf0\">. 10:95\u2013104.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">18. Vinayagamoorth V, et al. Newer variants of progressive familial intrahepatic cholestasis. 2021<\/span><span class=\"cf1\">. World J Hepatol<\/span><span class=\"cf0\">. 13(12):2024\u20132038.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">19. Bak\u0131r A<\/span><span class=\"cf1\">, et al. <\/span><span class=\"cf0\">The molecular landscape of progressive familial intrahepatic cholestasis in Turkey: Defining the molecular profiles and expanding the variant spectrum. <\/span><span class=\"cf1\">Ann Hum Genet <\/span><span class=\"cf0\">2022; 86:119\u2013126.\u00a0<\/span><\/em><\/p>\n<p><em><span class=\"cf0\">20. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on liver transplantation. <\/span><span class=\"cf1\">J Hepatol<\/span><span class=\"cf0\">. 2024;81(6):1040-1086.\u00a0<\/span><\/em><\/p>\n                <\/div>\n\n                <!-- If button is enabled then it's visible -->\n                \n            <\/div>\n        <\/div>\n    <\/section>\n","protected":false},"excerpt":{"rendered":"<p>Qu&#8217;est-ce que le FPIC adulte ?\u00a0 Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9<\/p>\n","protected":false},"author":11,"featured_media":114001,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[1192],"tags":[],"class_list":["post-114015","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rare-diseases-fr","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PFIC chez l&#039;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0 - Global<\/title>\n<meta name=\"description\" content=\"Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l&#039;absorption des graisses, ainsi qu&#039;\u00e0 l&#039;\u00e9limination des d\u00e9chets. 1\u20135 Lorsque la bile s&#039;accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. 1\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PFIC chez l&#039;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0 - Global\" \/>\n<meta property=\"og:description\" content=\"Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l&#039;absorption des graisses, ainsi qu&#039;\u00e0 l&#039;\u00e9limination des d\u00e9chets. 1\u20135 Lorsque la bile s&#039;accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. 1\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/\" \/>\n<meta property=\"og:site_name\" content=\"Global\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-01T12:09:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-01T12:22:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"591\" \/>\n\t<meta property=\"og:image:height\" content=\"312\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"heloisedetouchet\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ipsengroup\" \/>\n<meta name=\"twitter:site\" content=\"@ipsengroup\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"heloisedetouchet\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/\"},\"author\":{\"name\":\"heloisedetouchet\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#\\\/schema\\\/person\\\/2c275168b31beee81688f3c041877318\"},\"headline\":\"PFIC chez l&#8217;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0\",\"datePublished\":\"2026-10-01T12:09:44+00:00\",\"dateModified\":\"2026-10-01T12:22:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/\"},\"wordCount\":1176,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Image1.png\",\"articleSection\":[\"Maladies Rares\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/\",\"url\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/\",\"name\":\"PFIC chez l'adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0 - Global\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Image1.png\",\"datePublished\":\"2026-10-01T12:09:44+00:00\",\"dateModified\":\"2026-10-01T12:22:18+00:00\",\"description\":\"Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l'absorption des graisses, ainsi qu'\u00e0 l'\u00e9limination des d\u00e9chets. 1\u20135 Lorsque la bile s'accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. 1\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Image1.png\",\"contentUrl\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Image1.png\",\"width\":591,\"height\":312},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/rare-diseases-fr\\\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"PFIC chez l&#8217;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#website\",\"url\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/\",\"name\":\"Global\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#organization\",\"name\":\"IPSEN\",\"url\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/Latest_Ipsen-logo_168x48.svg\",\"contentUrl\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/Latest_Ipsen-logo_168x48.svg\",\"caption\":\"IPSEN\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/Ipsengroup\",\"https:\\\/\\\/x.com\\\/ipsengroup\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#\\\/schema\\\/person\\\/2c275168b31beee81688f3c041877318\",\"name\":\"heloisedetouchet\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a294050dc7df14814ce352dcd30bd2b11c1bf6f269c4edf2111b59216f02bb15?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a294050dc7df14814ce352dcd30bd2b11c1bf6f269c4edf2111b59216f02bb15?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a294050dc7df14814ce352dcd30bd2b11c1bf6f269c4edf2111b59216f02bb15?s=96&d=mm&r=g\",\"caption\":\"heloisedetouchet\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"PFIC chez l'adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0 - Global","description":"Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l'absorption des graisses, ainsi qu'\u00e0 l'\u00e9limination des d\u00e9chets. 1\u20135 Lorsque la bile s'accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. 1","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/","og_locale":"fr_FR","og_type":"article","og_title":"PFIC chez l'adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0 - Global","og_description":"Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l'absorption des graisses, ainsi qu'\u00e0 l'\u00e9limination des d\u00e9chets. 1\u20135 Lorsque la bile s'accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. 1","og_url":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/","og_site_name":"Global","article_published_time":"2026-10-01T12:09:44+00:00","article_modified_time":"2026-10-01T12:22:18+00:00","og_image":[{"width":591,"height":312,"url":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png","type":"image\/png"}],"author":"heloisedetouchet","twitter_card":"summary_large_image","twitter_creator":"@ipsengroup","twitter_site":"@ipsengroup","twitter_misc":{"Written by":"heloisedetouchet","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#article","isPartOf":{"@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/"},"author":{"name":"heloisedetouchet","@id":"https:\/\/www.ipsen.com\/fr\/#\/schema\/person\/2c275168b31beee81688f3c041877318"},"headline":"PFIC chez l&#8217;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0","datePublished":"2026-10-01T12:09:44+00:00","dateModified":"2026-10-01T12:22:18+00:00","mainEntityOfPage":{"@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/"},"wordCount":1176,"publisher":{"@id":"https:\/\/www.ipsen.com\/fr\/#organization"},"image":{"@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png","articleSection":["Maladies Rares"],"inLanguage":"fr-FR"},{"@type":"WebPage","@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/","url":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/","name":"PFIC chez l'adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0 - Global","isPartOf":{"@id":"https:\/\/www.ipsen.com\/fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#primaryimage"},"image":{"@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png","datePublished":"2026-10-01T12:09:44+00:00","dateModified":"2026-10-01T12:22:18+00:00","description":"Le PFIC est un groupe de maladies h\u00e9patiques h\u00e9r\u00e9ditaires rares qui affectent la capacit\u00e9 du corps \u00e0 transporter et circuler la bile, essentielle \u00e0 la digestion et \u00e0 l'absorption des graisses, ainsi qu'\u00e0 l'\u00e9limination des d\u00e9chets. 1\u20135 Lorsque la bile s'accumule dans le foie, elle peut endommager le foie et provoquer des sympt\u00f4mes tels que des d\u00e9mangeaisons. 1","breadcrumb":{"@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#primaryimage","url":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png","contentUrl":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png","width":591,"height":312},{"@type":"BreadcrumbList","@id":"https:\/\/www.ipsen.com\/fr\/actualites\/rare-diseases-fr\/pfic-chez-ladulte-pourquoi-certaines-personnes-passent-des-annees-a-chercher-des-reponses\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.ipsen.com\/fr\/"},{"@type":"ListItem","position":2,"name":"PFIC chez l&#8217;adulte : pourquoi certaines personnes passent des ann\u00e9es \u00e0 chercher des r\u00e9ponses\u00a0"}]},{"@type":"WebSite","@id":"https:\/\/www.ipsen.com\/fr\/#website","url":"https:\/\/www.ipsen.com\/fr\/","name":"Global","description":"","publisher":{"@id":"https:\/\/www.ipsen.com\/fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ipsen.com\/fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/www.ipsen.com\/fr\/#organization","name":"IPSEN","url":"https:\/\/www.ipsen.com\/fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/www.ipsen.com\/fr\/#\/schema\/logo\/image\/","url":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2023\/12\/Latest_Ipsen-logo_168x48.svg","contentUrl":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2023\/12\/Latest_Ipsen-logo_168x48.svg","caption":"IPSEN"},"image":{"@id":"https:\/\/www.ipsen.com\/fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Ipsengroup","https:\/\/x.com\/ipsengroup"]},{"@type":"Person","@id":"https:\/\/www.ipsen.com\/fr\/#\/schema\/person\/2c275168b31beee81688f3c041877318","name":"heloisedetouchet","image":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/secure.gravatar.com\/avatar\/a294050dc7df14814ce352dcd30bd2b11c1bf6f269c4edf2111b59216f02bb15?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a294050dc7df14814ce352dcd30bd2b11c1bf6f269c4edf2111b59216f02bb15?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a294050dc7df14814ce352dcd30bd2b11c1bf6f269c4edf2111b59216f02bb15?s=96&d=mm&r=g","caption":"heloisedetouchet"}}]}},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/10\/Image1.png","_links":{"self":[{"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/posts\/114015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/comments?post=114015"}],"version-history":[{"count":1,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/posts\/114015\/revisions"}],"predecessor-version":[{"id":114017,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/posts\/114015\/revisions\/114017"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/media\/114001"}],"wp:attachment":[{"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/media?parent=114015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/categories?post=114015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ipsen.com\/fr\/wp-json\/wp\/v2\/tags?post=114015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}