{"id":113987,"date":"2026-10-05T11:23:18","date_gmt":"2026-10-05T09:23:18","guid":{"rendered":"https:\/\/www.ipsen.com\/?p=113987"},"modified":"2026-10-05T14:26:54","modified_gmt":"2026-10-05T12:26:54","slug":"repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments","status":"publish","type":"post","link":"https:\/\/www.ipsen.com\/fr\/actualites\/science-2\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\/","title":{"rendered":"Repenser la d\u00e9couverte : comment les technologies de criblage de nouvelle g\u00e9n\u00e9ration red\u00e9finissent la recherche de nouveaux m\u00e9dicaments"},"content":{"rendered":"<p class=\"heading-para wp-block-paragraph\"><em>Par Mary Jane Hinrichs, SVP Head of Early Development and Innovation<\/em><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Dans la d\u00e9couverte de m\u00e9dicaments, l\u2019identification de la bonne cible biologique a toujours constitu\u00e9 une \u00e9tape \u00e0 la fois essentielle et complexe. Aujourd\u2019hui, l\u2019essor d\u2019outils de criblage de plus en plus puissants transforme profond\u00e9ment ce processus, marquant un changement majeur dans notre mani\u00e8re de passer des hypoth\u00e8ses scientifiques \u00e0 des m\u00e9dicaments \u00e0 fort potentiel de transformation. Les avanc\u00e9es en mati\u00e8re de criblage \u00e0 haut d\u00e9bit, de g\u00e9nomique et d\u2019analyses pilot\u00e9es par l\u2019intelligence artificielle permettent aux chercheurs d\u2019explorer la biologie des maladies \u00e0 une \u00e9chelle sans pr\u00e9c\u00e9dent, faisant \u00e9merger des opportunit\u00e9s qui \u00e9taient auparavant hors de port\u00e9e.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Cette \u00e9volution s\u2019inscrit pleinement dans les forces de l\u2019approche d\u2019Ipsen. Les avanc\u00e9es scientifiques les plus prometteuses \u00e9mergent de plus en plus du monde acad\u00e9mique et des biotechnologies, o\u00f9 les plateformes de criblage avanc\u00e9es r\u00e9v\u00e8lent de nouvelles cibles th\u00e9rapeutiques. En d\u00e9veloppant notre portefeuille gr\u00e2ce \u00e0 des partenariats au sein de cet \u00e9cosyst\u00e8me, nous pouvons acc\u00e9der tr\u00e8s t\u00f4t aux opportunit\u00e9s les plus prometteuses, en associant la rapidit\u00e9 de la d\u00e9couverte \u00e0 la source avec notre capacit\u00e9 \u00e0 acc\u00e9l\u00e9rer le d\u00e9veloppement. Gr\u00e2ce \u00e0 nos expertises cl\u00e9s, allant de la pharmaceutique clinique (s\u00e9lection et formulation d\u2019un m\u00e9dicament) \u00e0 la mod\u00e9lisation pharmacom\u00e9trique (pr\u00e9diction du comportement d\u2019un m\u00e9dicament dans l\u2019organisme) et \u00e0 la translation des biomarqueurs (mesure de l\u2019effet th\u00e9rapeutique), nous transformons des mol\u00e9cules en m\u00e9dicaments.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Un exemple embl\u00e9matique de cette approche est notre conjugu\u00e9 anticorps-m\u00e9dicament (ADC), IPN60300, d\u00e9velopp\u00e9 en partenariat avec Foreseen Biotechnology. En juillet 2024, Ipsen a obtenu une licence mondiale exclusive pour le d\u00e9veloppement, la fabrication et la commercialisation de cet ADC innovant, et nous avons depuis acc\u00e9l\u00e9r\u00e9 son d\u00e9veloppement jusqu\u2019aux essais cliniques de phase I\/II. La nouvelle cible th\u00e9rapeutique, ITGA2, a \u00e9t\u00e9 identifi\u00e9e gr\u00e2ce \u00e0 la plateforme de prot\u00e9omique optimis\u00e9e pour la translation et renforc\u00e9e par l\u2019apprentissage automatique (Machine Learning Enabled Translational-Optimized Proteomics System) de Foreseen, puis valid\u00e9e au moyen de sa plateforme de criblage \u00e0 haut d\u00e9bit. Cette d\u00e9couverte a repos\u00e9 sur l\u2019analyse d\u2019une vaste collection d\u2019\u00e9chantillons cliniques afin d\u2019identifier de nouvelles cibles sp\u00e9cifiques \u00e0 la maladie, \u00e9troitement li\u00e9es \u00e0 sa biologie et \u00e0 son impact sur les patients. De telles approches prot\u00e9omiques ont le potentiel d\u2019am\u00e9liorer les probabilit\u00e9s de succ\u00e8s dans l\u2019identification de cibles \u00e0 fort impact th\u00e9rapeutique.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Plus important encore, la combinaison des expertises nous permet d\u2019aller au-del\u00e0 des progr\u00e8s incr\u00e9mentaux. En s\u00e9lectionnant plus t\u00f4t les bonnes cibles et les bonnes mol\u00e9cules, puis en acc\u00e9l\u00e9rant leur d\u00e9veloppement gr\u00e2ce \u00e0 une approche connect\u00e9e et fond\u00e9e sur les donn\u00e9es, nous cr\u00e9ons les conditions n\u00e9cessaires au d\u00e9veloppement de m\u00e9dicaments \u00ab best-in-class \u00bb et \u00ab first-in-class \u00bb dans des domaines o\u00f9 les besoins m\u00e9dicaux non satisfaits sont importants.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Au final, notre ambition est claire : transformer plus rapidement des hypoth\u00e8ses scientifiques en m\u00e9dicaments capables de changer la vie des patients. Car la v\u00e9ritable promesse du criblage ne r\u00e9side pas seulement dans ce qui est d\u00e9couvert, mais aussi dans notre capacit\u00e9 \u00e0 traduire ces d\u00e9couvertes avec rapidit\u00e9 et confiance en b\u00e9n\u00e9fices concrets pour les patients.<\/p>","protected":false},"excerpt":{"rendered":"<p>Par Mary Jane Hinrichs, SVP Head of Early Development and Innovation Dans la d\u00e9couverte de m\u00e9dicaments, l\u2019identification de la bonne<\/p>\n","protected":false},"author":11,"featured_media":113985,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[81827],"tags":[],"class_list":["post-113987","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-2","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Repenser la d\u00e9couverte : comment les technologies de criblage de nouvelle g\u00e9n\u00e9ration red\u00e9finissent la recherche de nouveaux m\u00e9dicaments - Global<\/title>\n<meta name=\"description\" content=\"Dans la d\u00e9couverte de m\u00e9dicaments, l\u2019identification de la bonne cible biologique a toujours constitu\u00e9 une \u00e9tape \u00e0 la fois essentielle et complexe. Aujourd\u2019hui, l\u2019essor d\u2019outils de criblage de plus en plus puissants transforme profond\u00e9ment ce processus, marquant un changement majeur dans notre mani\u00e8re de passer des hypoth\u00e8ses scientifiques \u00e0 des m\u00e9dicaments \u00e0 fort potentiel de transformation. 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Aujourd\u2019hui, l\u2019essor d\u2019outils de criblage de plus en plus puissants transforme profond\u00e9ment ce processus, marquant un changement majeur dans notre mani\u00e8re de passer des hypoth\u00e8ses scientifiques \u00e0 des m\u00e9dicaments \u00e0 fort potentiel de transformation. Les avanc\u00e9es en mati\u00e8re de criblage \u00e0 haut d\u00e9bit, de g\u00e9nomique et d\u2019analyses pilot\u00e9es par l\u2019intelligence artificielle permettent aux chercheurs d\u2019explorer la biologie des maladies \u00e0 une \u00e9chelle sans pr\u00e9c\u00e9dent, faisant \u00e9merger des opportunit\u00e9s qui \u00e9taient auparavant hors de port\u00e9e\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ipsen.com\/fr\/actualites\/science-2\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\/\" \/>\n<meta property=\"og:site_name\" content=\"Global\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-05T09:23:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-05T12:26:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/09\/Mary_Jane_Hinrichs_seamless_1082x620.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1082\" \/>\n\t<meta property=\"og:image:height\" content=\"620\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"heloisedetouchet\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ipsengroup\" \/>\n<meta name=\"twitter:site\" content=\"@ipsengroup\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"heloisedetouchet\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/science-2\\\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/science-2\\\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\\\/\"},\"author\":{\"name\":\"heloisedetouchet\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#\\\/schema\\\/person\\\/2c275168b31beee81688f3c041877318\"},\"headline\":\"Repenser la d\u00e9couverte : comment les technologies de criblage de nouvelle g\u00e9n\u00e9ration red\u00e9finissent la recherche de nouveaux m\u00e9dicaments\",\"datePublished\":\"2026-10-05T09:23:18+00:00\",\"dateModified\":\"2026-10-05T12:26:54+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/science-2\\\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\\\/\"},\"wordCount\":610,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/science-2\\\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ipsen.com\\\/wp-content\\\/uploads\\\/2026\\\/09\\\/Mary_Jane_Hinrichs_seamless_1082x620.jpg\",\"articleSection\":[\"Science\"],\"inLanguage\":\"fr-FR\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/science-2\\\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\\\/\",\"url\":\"https:\\\/\\\/www.ipsen.com\\\/fr\\\/actualites\\\/science-2\\\/repenser-la-decouverte-comment-les-technologies-de-criblage-de-nouvelle-generation-redefinissent-la-recherche-de-nouveaux-medicaments\\\/\",\"name\":\"Repenser la d\u00e9couverte : comment les technologies de criblage de nouvelle g\u00e9n\u00e9ration red\u00e9finissent la recherche de nouveaux m\u00e9dicaments - 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