{"id":108775,"date":"2026-07-21T09:00:00","date_gmt":"2026-07-21T07:00:00","guid":{"rendered":"https:\/\/www.ipsen.com\/?p=108775"},"modified":"2026-07-21T11:24:07","modified_gmt":"2026-07-21T09:24:07","slug":"quand-les-acides-biliaires-prennent-une-dimension-plus-large-comment-la-biologie-de-la-cholestase-transforme-la-recherche-sur-les-maladies-hepatiques-rares","status":"publish","type":"post","link":"https:\/\/www.ipsen.com\/fr\/actualites\/science-2\/quand-les-acides-biliaires-prennent-une-dimension-plus-large-comment-la-biologie-de-la-cholestase-transforme-la-recherche-sur-les-maladies-hepatiques-rares\/","title":{"rendered":"Quand les acides biliaires\u00a0prennent une dimension plus large\u00a0: comment la biologie de la cholestase transforme la recherche sur les maladies h\u00e9patiques rares\u00a0"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" height=\"587\" width=\"1024\" src=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/07\/Jennifer-Schranz.png?w=1024\" alt=\"\" class=\"wp-image-108773\" style=\"aspect-ratio:1.7457621614600247;width:549px;height:auto\" srcset=\"https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/07\/Jennifer-Schranz.png 1082w, https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/07\/Jennifer-Schranz.png?resize=150,86 150w, https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/07\/Jennifer-Schranz.png?resize=300,172 300w, https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/07\/Jennifer-Schranz.png?resize=768,440 768w, https:\/\/www.ipsen.com\/wp-content\/uploads\/2026\/07\/Jennifer-Schranz.png?resize=1024,587 1024w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n<p class=\"has-white-color has-text-color has-link-color wp-elements-7e4ac651328708ea719ac0894fa30934 heading-para wp-block-paragraph\">.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><em>Jennifer Schranz, Senior Vice President, Head of Rare Diseases<\/em>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Le co\u00fbt humain d\u2019un syst\u00e8me en d\u00e9s\u00e9quilibre<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Au fil des ann\u00e9es, j\u2019ai pu constater de premi\u00e8re main \u00e0 quel point une fatigue accablante et des d\u00e9mangeaisons incessantes peuvent d\u00e9finir le quotidien de nombreuses personnes vivant avec une maladie h\u00e9patique cholestatique rare. Ces sympt\u00f4mes perturbent le\u00a0sommeil,\u00a0\u00a0la\u00a0vie professionnelle\u00a0et la vie familiale \u2013 autant de signes visibles d\u2019un organisme qui peine \u00e0 maintenir son \u00e9quilibre biologique.\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Ils sont la cons\u00e9quence de la cholestase, une situation dans laquelle l\u2019\u00e9coulement de la bile depuis le foie est alt\u00e9r\u00e9, entra\u00eenant une accumulation toxique d\u2019acides biliaires qui aggrave les sympt\u00f4mes et favorise une atteinte h\u00e9patique progressive. Malgr\u00e9 les avanc\u00e9es de nos connaissances, les options th\u00e9rapeutiques restent limit\u00e9es. Cela soul\u00e8ve une question essentielle : et si la cl\u00e9 de nouveaux traitements r\u00e9sidait dans une meilleure compr\u00e9hension du r\u00f4le plus large que jouent les acides biliaires dans l\u2019organisme ?\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Les acides biliaires :\u00a0\u00a0\u00a0une compr\u00e9hension approfondie\u00a0qui fa\u00e7onne l\u2019avenir de la recherche<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Pendant longtemps, les acides biliaires ont principalement \u00e9t\u00e9 \u00e9tudi\u00e9s sous l\u2019angle des dommages que leur accumulation peut provoquer dans le foie. Mais les progr\u00e8s r\u00e9alis\u00e9s dans la compr\u00e9hension de la biologie de la cholestase r\u00e9v\u00e8lent aujourd\u2019hui une r\u00e9alit\u00e9 bien plus vaste. Les acides biliaires sont d\u00e9sormais reconnus comme de puissantes mol\u00e9cules de signalisation qui influencent le m\u00e9tabolisme, l\u2019inflammation et les fonctions immunitaires dans l\u2019ensemble de l\u2019organisme.\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">\u00c0 mesure que cette compr\u00e9hension s\u2019est approfondie, l\u2019approche des chercheurs vis-\u00e0-vis des maladies h\u00e9patiques cholestatiques rares a \u00e9volu\u00e9. L\u2019attention ne se porte plus uniquement sur la perturbation du flux biliaire, mais \u00e9galement sur les d\u00e9s\u00e9quilibres biologiques qui alimentent la progression de la maladie. Dans le domaine des maladies h\u00e9patiques rares, ce changement de perspective ouvre de nouvelles voies th\u00e9rapeutiques. Aujourd\u2019hui, des approches telles que les inhibiteurs de l\u2019IBAT, les\u00a0agonistes des PPAR, les agonistes du FXR ou encore les th\u00e9rapies modulant le microbiote sont explor\u00e9es, refl\u00e9tant une compr\u00e9hension plus approfondie de la biologie des acides biliaires.\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Ce qui est\u00a0particuli\u00e8rement\u00a0\u00a0prometteur, c\u2019est la mani\u00e8re dont ces avanc\u00e9es commencent \u00e0 transformer\u00a0notre\u00a0\u00a0approche\u00a0de la prise en charge. En intervenant plus t\u00f4t et en ciblant les m\u00e9canismes qui alimentent la maladie, nous pouvons commencer \u00e0 aller au-del\u00e0 du simple contr\u00f4le des sympt\u00f4mes. Des biomarqueurs tels que la phosphatase alcaline (PAL) \u2014 un marqueur de cholestase dont la normalisation est associ\u00e9e \u00e0 de meilleurs r\u00e9sultats \u00e0 long terme \u2014 contribuent de plus en plus \u00e0 orienter les d\u00e9cisions th\u00e9rapeutiques.\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Ipsen : mettre cette science au service des patients<\/strong>\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Chez Ipsen, notre approche des maladies h\u00e9patiques rares repose sur un changement de paradigme d\u00e9lib\u00e9r\u00e9 : consid\u00e9rer les acides biliaires comme\u00a0un\u00a0\u00a0un\u00a0facteur cl\u00e9\u00a0de la maladie et du\u00a0fardeau\u00a0\u00a0qu\u2019elle\u00a0repr\u00e9sente\u00a0au quotidien\u00a0pour les\u00a0patients \u00e0 l\u2019\u00e9chelle de l\u2019organisme tout entier. Cette vision guide la mani\u00e8re dont nous acc\u00e9l\u00e9rons notre recherche, en orientant les voies biologiques que nous ciblons et la conception de nos essais cliniques afin de g\u00e9n\u00e9rer un impact significatif.\u00a0<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">\u00c0 travers cinq maladies cholestatiques h\u00e9patiques rares, nous faisons progresser une strat\u00e9gie de recherche cibl\u00e9e fond\u00e9e sur les connaissances \u00e9mergentes de la biologie des acides biliaires, en mettant cette compr\u00e9hension au service du d\u00e9veloppement de nouvelles approches th\u00e9rapeutiques.\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>. Jennifer Schranz, Senior Vice President, Head of Rare Diseases\u00a0 Le co\u00fbt humain d\u2019un syst\u00e8me en d\u00e9s\u00e9quilibre\u00a0 Au fil des<\/p>\n","protected":false},"author":11,"featured_media":108773,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[81827],"tags":[],"class_list":["post-108775","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-2","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Quand les acides biliaires\u00a0prennent une dimension plus large\u00a0: comment la biologie de la cholestase transforme la recherche sur les maladies h\u00e9patiques rares\u00a0 - Global<\/title>\n<meta name=\"description\" content=\"Au fil des ann\u00e9es, j\u2019ai pu constater de premi\u00e8re main \u00e0 quel point une fatigue accablante et des d\u00e9mangeaisons incessantes peuvent d\u00e9finir le quotidien de nombreuses personnes vivant avec une maladie h\u00e9patique cholestatique rare. 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