{"id":102894,"date":"2026-04-04T08:00:00","date_gmt":"2026-04-04T06:00:00","guid":{"rendered":"https:\/\/www.ipsen.com\/?p=102894"},"modified":"2026-04-03T17:16:45","modified_gmt":"2026-04-03T15:16:45","slug":"concentration-strategique-alexis-cocozaki-sur-la-voie-de-la-decouverte-amont-chez-ipsen","status":"publish","type":"post","link":"https:\/\/www.ipsen.com\/fr\/actualites\/science-2\/concentration-strategique-alexis-cocozaki-sur-la-voie-de-la-decouverte-amont-chez-ipsen\/","title":{"rendered":"Concentration\u00a0strat\u00e9gique\u00a0: Alexis\u00a0Cocozaki\u00a0sur la\u00a0voie\u00a0de la\u00a0d\u00e9couverte\u00a0amont\u00a0chez Ipsen\u00a0"},"content":{"rendered":"\n

\u00ab Pour r\u00e9ussir dans ce domaine, il faut avoir une certaine tol\u00e9rance \u00e0 l\u2019\u00e9chec et \u00e0 la prise de risque. \u00bb <\/p>\n\n\n\n

Au c\u0153ur des efforts de d\u00e9couverte amont d\u2019Ipsen se trouve une question d\u2019ad\u00e9quation\u2014comment une mol\u00e9cule interagit avec une prot\u00e9ine pertinente pour la maladie, et ce que cela signifie pour le potentiel th\u00e9rapeutique. L\u2019\u00e9quipe d\u2019Alexis Cocozaki se concentre pr\u00e9cis\u00e9ment sur cet espace, en appliquant des techniques biophysiques et de biologie structurale pour \u00e9valuer et optimiser de nouveaux actifs au niveau atomique. <\/p>\n\n\n\n

\u00ab Nous isolons des cibles prot\u00e9iques sp\u00e9cifiques et r\u00e9alisons des essais biochimiques in vitro afin d\u2019identifier les mol\u00e9cules qui inhibent ces cibles \u00bb, explique Alexis. Une fois qu\u2019un compos\u00e9 montre un potentiel, ils passent \u00e0 la validation structurale. \u00ab Nous d\u00e9terminons la structure de la prot\u00e9ine li\u00e9e \u00e0 la mol\u00e9cule pour aider les chimistes \u00e0 l\u2019am\u00e9liorer. \u00bb <\/p>\n\n\n\n

Ce travail est fondamental pour la conception de m\u00e9dicaments bas\u00e9e sur la structure et pour le tri pr\u00e9coce des actifs. Lorsqu\u2019un compos\u00e9 atteint le d\u00e9veloppement exploratoire, une grande partie de la logique mol\u00e9culaire a d\u00e9j\u00e0 \u00e9t\u00e9 \u00e9tablie. \u00ab Il s\u2019agit de r\u00e9duire l\u2019incertitude t\u00f4t\u2014afin que les \u00e9quipes de phases ult\u00e9rieures puissent avancer en confiance. \u00bb <\/p>\n\n\n\n

Tr\u00e8s t\u00f4t, Alexis a travaill\u00e9 en diagnostic hospitalier\u2014traitant des \u00e9chantillons de patients, analysant des infections et g\u00e9n\u00e9rant des donn\u00e9es. Cette exposition clinique lui a donn\u00e9 un sentiment durable d\u2019urgence. \u00ab Cela m\u2019a donn\u00e9 envie de comprendre ce qui se passait r\u00e9ellement au niveau mol\u00e9culaire. C\u2019est l\u00e0 que le changement commence. \u00bb <\/p>\n\n\n\n

Il est convaincu que la biologie structurale est en pleine \u00e9volution. Les outils de pr\u00e9diction des structures prot\u00e9iques, associ\u00e9s \u00e0 la ressource collective qu\u2019est l\u2019intelligence artificielle, commencent \u00e0 acc\u00e9l\u00e9rer un domaine autrefois d\u00e9fini par des mois d\u2019essais et d\u2019erreurs. \u00ab L\u2019id\u00e9e de pouvoir mettre en commun tout ce qui existe dans des ressources open source collectives pour nous guider sur ce que nous devons cibler ensuite permettra \u00e0 l\u2019industrie d\u2019avancer rapidement. \u00bb <\/p>\n\n\n\n

Par ses efforts pour ancrer la structure dans la strat\u00e9gie, Alexis contribue \u00e0 fa\u00e7onner l\u2019approche d\u2019Ipsen en mati\u00e8re de d\u00e9couverte de pr\u00e9cision\u2014o\u00f9 l\u2019insight cr\u00e9e l\u2019\u00e9lan, et chaque atome cartographi\u00e9 repr\u00e9sente un pas vers ce qui compte ensuite. <\/p>\n","protected":false},"excerpt":{"rendered":"

\u00ab Pour r\u00e9ussir dans ce domaine, il faut avoir une certaine tol\u00e9rance \u00e0 l\u2019\u00e9chec et \u00e0 la prise de risque. \u00bb  Au c\u0153ur des efforts de d\u00e9couverte amont d\u2019Ipsen se trouve une question d\u2019ad\u00e9quation\u2014comment une mol\u00e9cule interagit avec une prot\u00e9ine pertinente pour la maladie, et ce que cela signifie pour le potentiel th\u00e9rapeutique. L\u2019\u00e9quipe d\u2019Alexis Cocozaki se concentre pr\u00e9cis\u00e9ment sur cet espace, en appliquant des techniques biophysiques et de biologie structurale pour \u00e9valuer et optimiser de<\/p>\n","protected":false},"author":97,"featured_media":102892,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[81827],"tags":[],"class_list":["post-102894","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-2","entry"],"acf":[],"yoast_head":"\nConcentration\u00a0strat\u00e9gique\u00a0: Alexis\u00a0Cocozaki\u00a0sur la\u00a0voie\u00a0de la\u00a0d\u00e9couverte\u00a0amont\u00a0chez Ipsen\u00a0 - 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