{"id":203,"date":"2022-05-04T06:54:00","date_gmt":"2022-05-04T04:54:00","guid":{"rendered":"https:\/\/www.ipsen.com\/canada\/?post_type=press_release&#038;p=203"},"modified":"2024-08-20T09:04:20","modified_gmt":"2024-08-20T07:04:20","slug":"health-canada-approves-ipsens-cabometyx-cabozantinib-for-patients-with-previously-treated-radioactive-iodine-refractory-or-ineligible-differentiated-thyroid-cancer","status":"publish","type":"press_release","link":"https:\/\/www.ipsen.com\/canada\/press-releases\/health-canada-approves-ipsens-cabometyx-cabozantinib-for-patients-with-previously-treated-radioactive-iodine-refractory-or-ineligible-differentiated-thyroid-cancer\/","title":{"rendered":"Health Canada approves Ipsen\u2019s CABOMETYX\u00ae (cabozantinib) for Patients with Previously Treated Radioactive Iodine-Refractory or Ineligible Differentiated Thyroid Cancer"},"content":{"rendered":"<p class=\"heading-para wp-block-paragraph\"><em>Pivotal phase III trial data showed CABOMETYX<sup>\u00ae<\/sup>\u00a0demonstrated a significant improvement in progression-free survival.<sup><strong>1<\/strong><\/sup><\/em><\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>Mississauga, ON \u2013 May 4, 2022<\/strong>\u00a0\u2013 Ipsen Biopharmaceuticals Canada Inc. today announced the Health Canada approval of CABOMETYX<sup>\u00ae<\/sup>\u00a0(cabozantinib) for the treatment of adults with locally advanced or metastatic differentiated thyroid carcinoma (DTC) that has progressed following prior VEGFR-targeted therapy and who are radioactive iodine-refractory (RAI-R) or ineligible.<sup>1<\/sup>\u00a0CABOMETYX<sup>\u00ae<\/sup>\u00a0was granted priority review for DTC by Health Canada because of the significant unmet need it fills for this patient population.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">\u201cPatients living with RAI-R DTC have limited treatment options, and often go without second line treatment even though they are well enough to receive one,\u201d said Dr. Sebastien Hotte, medical oncologist, the Juravinski Cancer Centre, Associate Professor, McMaster University. \u201cThe progression-free survival benefit demonstrated in the phase III COSMIC-311 trial means CABOMETYX<sup>\u00ae<\/sup>\u00a0is of significant importance for patients I see every day. Thanks to this approval, patients who thought they had run out of options may have a chance for more time without disease progression.\u201d<\/p>\n\n<p class=\"heading-para wp-block-paragraph\">It is estimated that 6,700 Canadians were diagnosed with thyroid cancer in 2021, with DTC accounting for up to 95% of cases.<sup>2,3<\/sup>\u00a0The incidence of thyroid cancer is three times higher in women than men and is the ninth most common cancer in the world.<sup>4<\/sup>\u00a0Most commonly treated with surgery, followed by ablation of the remaining thyroid tissue with RAI, approximately 5 to 15% of DTC cases become refractory to RAI treatment.<sup>5\u00a0<\/sup>Patients who develop RAI-refractory DTC have a poor prognosis with an average estimated survival of three to five years.<sup>6<\/sup><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">This approval is based on the Phase III COSMIC-311 trial, which demonstrated that CABOMETYX<sup>\u00ae<\/sup>\u00a0showed statistically significant improvement in progression-free survival for patients vs placebo. In the primary analysis conducted after median follow-up of 6.2 months, CABOMETYX<sup>\u00ae<\/sup>\u00a0was associated with a 78% reduction in risk of disease progression or death versus placebo (hazard ratio [HR]: 0.22; 96% confidence interval [CI]: 0.13-0.36; p&gt;0.0001).<sup>1<\/sup><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">\u201cWe\u2019re proud to make new treatment options like CABOMETYX<sup>\u00ae<\/sup>\u00a0available for patients suffering from DTC who previously had no other options after progression on a VEGF therapy,\u201d said Ed Dybka, General Manager, Ipsen Biopharmaceuticals Canada Inc. \u201cWith this approval, CABOMETYX<sup>\u00ae<\/sup>\u00a0now has five indications, underscoring Ipsen\u2019s commitment to addressing unmet patient needs and the potential for CABOMETYX<sup>\u00ae<\/sup>\u00a0to improve the lives of patients and their families.\u201d<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>About the COSMIC-311 trial<\/strong><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">COSMIC-311 is a randomized, double-blind, placebo-controlled Phase III trial that enrolled 258 patients with locally advanced or metastatic differentiated thyroid cancer (papillary thyroid carcinoma or follicular thyroid carcinoma) that had progressed following prior VEGFR-targeted therapy and were radioactive iodine (RAI)-refractory or ineligible.<sup>1<\/sup>\u00a0Patients were randomized into a 2:1 ratio to receive either CABOMETYX<sup>\u00ae<\/sup>\u00a060 mg or placebo once-daily.<sup>1<\/sup>\u00a0The primary endpoints were progression-free survival (PFS) in the intention-to-treat population as well as objective response rate (ORR) in the first 100 randomly assigned patients (objective response rate intention-to-treat [OITT] population), both evaluated by a blinded independent radiology committee. Additional endpoints include safety, overall survival and quality of life.<sup>7\u00a0<\/sup>Exelixis is the sponsor of COSMIC-311, and Ipsen is co-funding the trial. More information about this trial is available at\u00a0<strong><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03690388\" target=\"_blank\" rel=\"noreferrer noopener\">ClinicalTrials.gov<\/a><\/strong>.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>About\u00a0<\/strong><strong>CABOMETYX<sup>\u00ae<\/sup>\u00a0(cabozantinib)<\/strong><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">CABOMETYX<sup>\u00ae<\/sup>\u00a0is the first multi-targeted tyrosine kinase inhibitor (TKI) to target VEGFR, MET \u00a0and AXL pathways that are involved in tumour progression. CABOMETYX<sup>\u00ae\u00a0<\/sup>is a multi-kinase inhibitor. It works by blocking the action of proteins called receptor tyrosine kinases (RTKs). RTKs are involved in cell growth and the development of new blood vessels. These proteins can be present in high amounts in cancer cells. By blocking their action, CABOMETYX<sup>\u00ae<\/sup>\u00a0can slow down how fast the tumour grows, help to block the blood supply that the cancer needs and may increase the length of time before the cancer gets worse.<sup>1<\/sup><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">CABOMETYX<sup>\u00ae\u00a0<\/sup>has three indications for the treatment of patients with advanced renal cell carcinoma (RCC) and one indication for the treatment of patients with advanced hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>About Ipsen in North America<\/strong><\/p>\n\n<p class=\"heading-para wp-block-paragraph\">Ipsen is a global biopharmaceutical company focused on innovation and specialty care. At Ipsen, we focus our resources, investments and energy on discovering, developing and commercializing medicines in three key therapeutic areas \u2013 Oncology, Rare Disease and Neuroscience. Our North American operations are located in Cambridge, Massachusetts, one of the company\u2019s three global hubs. Based in the heart of Kendall Square, our fully integrated biopharmaceutical business includes Commercial, Research &amp; Development, Manufacturing, and Business Development. Combined with our Canadian headquarters in Mississauga, Ontario, and other locations, we employ approximately 600 people in North America. For more information please visit\u00a0<strong><a href=\"https:\/\/www.ipsen.com\/canadaen\/\">www.ipsen.com\/canadaEN<\/a><\/strong>.<\/p>\n\n<p class=\"heading-para wp-block-paragraph\"><strong>For further information:<\/strong><\/p>\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><tbody><tr><td>Kendra Stephenson&nbsp;<br>Proof Strategies<br><a href=\"mailto:kstephenson@getproof.com\"><strong>kstephenson@getproof.com<\/strong><\/a><br>(416) 969-2658&nbsp; &nbsp;&nbsp;<\/td><td>Maryann Quinn<br>Ipsen Biopharmaceuticals<br><strong><a href=\"mailto:maryann.quinn@ipsen.com\">maryann.quinn@ipsen.com<\/a><\/strong><br>(857) 529-1151<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<ol class=\"wp-block-list\">\n<li>CABOMETYX<sup>\u00ae<\/sup>&nbsp;Product Monograph. Ipsen Biopharmaceuticals Canada Inc. 27 April 2022<\/li>\n\n\n\n<li>Canadian Cancer Society. Thyroid Cancer Statistics.&nbsp;<a href=\"https:\/\/cancer.ca\/en\/cancer-information\/cancer-types\/thyroid\/statistics#:~:text=Incidence%20and%20mortality&amp;text=6%2C700%20Canadians%20will%20be%20diagnosed,130%20will%20die%20from%20it\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/cancer.ca\/en\/cancer-information\/cancer-types\/thyroid\/statistics#:~:text=Incidence%20and%20mortality&amp;text=6%2C700%20Canadians%20will%20be%20diagnosed,130%20will%20die%20from%20it<\/strong><\/a>. Last accessed April 26, 2022.<\/li>\n\n\n\n<li>Cancer.Net. ASCO. Thyroid Cancer: Introduction.&nbsp;<a href=\"https:\/\/www.cancer.net\/cancer-types\/thyroid-cancer\/introduction\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/www.cancer.net\/cancer-types\/thyroid-cancer\/introduction<\/strong><\/a>. Last accessed April 26, 2022.<\/li>\n\n\n\n<li>Sung. H&nbsp;<em>et al<\/em>. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries: CA: A Cancer Journal for Clinicians. Doi: 10.3322\/caac.21660.<\/li>\n\n\n\n<li>Worden F. Treatment strategies for radioactive iodine-refractory differentiated thyroid cancer.&nbsp;<em>Ther Adv Med Oncol<\/em>. 6:267\u2013279. doi: 10.1177\/1758834014548188.<\/li>\n\n\n\n<li>Fugazzola L.&nbsp;<em>et al<\/em>. 2019 European Thyroid Association Guidelines for the Treatment and Follow-Up of Advanced Radioiodine-Refractory Thyroid Cancer.&nbsp;<em>Eur Thyroid J.&nbsp;<\/em>2019;8:227\u2013245. doi: 10.1159\/000502229.<\/li>\n\n\n\n<li>Brose et al., Cabozantinib for radioiodine-refractory differentiated thyroid cancer (COSMIC-311): a randomized, double-blind, placebo-controlled, phase 3 trial. Lancet Oncology. 2021; 22:8.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Pivotal phase III trial data showed CABOMETYX\u00ae\u00a0demonstrated a significant improvement in progression-free survival.1 Mississauga, ON \u2013 May 4, 2022\u00a0\u2013 Ipsen Biopharmaceuticals Canada Inc. today announced the Health Canada approval of CABOMETYX\u00ae\u00a0(cabozantinib) for the treatment of adults with locally advanced or metastatic differentiated thyroid carcinoma (DTC) that has progressed following prior VEGFR-targeted therapy and who are<\/p>\n","protected":false},"author":2,"template":"","categories":[37],"tags":[],"class_list":["post-203","press_release","type-press_release","status-publish","hentry","category-oncologie-communiques-de-presse","entry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Health Canada approves Ipsen\u2019s CABOMETYX\u00ae (cabozantinib) for 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