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Spasticity is one of the most disabling problems for people with a neurological condition. It not only reduces functionality but is often painful. Caring for a patient with spasticity can be extremely difficult for the care taker and family. The advent of botulinum toxin has revolutionized the management of spasticity.

In neurodegenerative conditions, Ipsen has synthesized several original classes of chimeric compounds, i.e. compounds capable of performing several pharmacological activities simultaneously and used to protect mitochondria (intracellular organs responsible for the production of energy) in connection with neurodegenerative conditions, such as Parkinson’s and Huntington’s disease or amyotrophic lateral sclerosis.

TARGETED DISEASES

DYSTONIA

Dystonia is a motor disorder characterized by involuntary and sustained muscle contractions resulting in abnormal positions, always identical in the same patient. 

  • Blepharospasm

Blepharospasm is an involuntary contraction of the muscles located around the eyes, causing the eyelids to close intermittently or for prolonged periods of time. It starts with involuntary blinking, which then becomes increasingly frequent, and, after several weeks, leads to spasms with full closure of the eyelids lasting from a few seconds to several minutes. Blepharospasm may lead to a functional blindness representing a major handicap for the patient.

  • Cervical dystonia

Cervical dystonia is characterized by intermittent spasms of the neck muscles, causing a head tilt. This condition is painful and impairs social life with task specific limitation (e.g., inability to drive).

  • Hemifacial spasm

Hemifacial spasm is a contraction of the muscles located on one side of the face. In its least severe form, hemifacial spasm causes only a mild discomfort. However, it can become very unsightly and affect the patient's social life. In the most serious cases, uncontrolled eyelid closure may impair vision. However, as only one eye is affected, hemifacial spasm is not associated with total vision loss.

 

SPASTICITY

Spasticity is more or less a marked tendency of muscles to contract.

  •  Arm spasticity

Spasticity is observed in most people with certain types of lesions of the central nervous system. It is characterized by an abnormal increase in muscle tone with rigidity and exaggeration of the tendon reflexes.

  • Dynamic equinus foot deformity

Brain damage may cause lower limb spasticity leading to equinus foot deformity. Equinus foot deformity is due to a contraction of the calf muscles which may result in an inability to perform a dorsiflexion of the foot and toes. The normal gait is replaced by a gait on tiptoes. This anomaly affects the balance with abnormal pressure on the ankle. This deformity is said to be dynamic when the muscle can still be stretched (the presence of fibrosis may prevent such stretching).